Subventricular zone

Methods Used to Detect Newly Generated Cells 

Markers Used for Cell Proliferation and Stem/Progenitor Cells 

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GUal precursors in the ventricular and subventricular zones can also express opioid receptors (Zhu et al. 1998 Reznikov et al. 1999 Stiene-Martin et al. 2001 Kim et al. 2006 Tripathi et al. 2008). Immature glia and adult progenitors express opioid receptors, which affect ceUular maturation (Stiene-Martin and Hauser 1990, 1991 Stiene-Martin et al. 1991 Persson et al. 2003,2006) and cell fate decisions (Kim et al. 2006). Importantly, gUal precursors (Khurdayan et al. 2004 Lawrence et al. 2004 Buch et al. 2007), and espedaUy immature oUgodendroglia (Khurdayan et al. 2004 Hauser et al. 2008), also appear to be vulnerable to opioids and HIV-1 proteins. 

Tripathi A, Khurshid N, Kumar P, Iyengar S (2008) Expression of delta- and mu-opioid receptors in the ventricular and subventricular zones of the developing human neocortex. Neurosci Res 61 257-270... 

FIGURE 29-5 In the adult rodent brain, dividing cells in the subventricular zone adjacent to the lateral ventricle migrate in the rostral migratory stream (RMS) and differentiate into olfactory neurons in the olfactory bulb (OB). This is one site of neuronal turnover in the adult that appears to result from persistent generation of neurons from adult CNS stem cells. CIS, cerebellum NC, neocortex. 

Gross, R. E., Mehler, M. F., Mabie, P. C., Santschi, L., Ngo, P. and Kessler, J. A. Promotion of astroglial lineage commitment from mammalian subventricular zone progenitor cells by bone morphogenetic proteins. Neuron 17 1-20,1996. 

Lois, C. and Alvarez Buylla, A. Proliferating subventricular zone cells in the adult mammalian forebrain can differentiate into neurons and glia. Proc. Natl Acad. Sci. U.S.A. 90 2074-2077,1993. 

Alvarez Buylla, A. and Garcia Verdugo, J. M. Neurogenesis in adult subventricular zone. /. Neurosci. 22 629-634,2002. 

Luskin, M. B. Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11 173-189,1993. 

Anderson, S.A., Qiu, M., Bulfone, A., Eisenstat, D.D., Meneses, J., Pedersen, R., and Rubenstein, J.L. (1997) Mutations of the hom-eobox genes Dlx-1 and Dlx-2 disrupt the striatal subventricular zone and differentiation of late born striatal neurons. Neuron 19 27-37. 

Banasr, M., , M., Printemps, R., Daszuta, A. (2004). Serotonin-induced increases in adult cell proliferation and neurogenesis are mediated through different and common 5-HT receptor subtypes in the dentate gyrus and the subventricular zone. Neuropsychopharmacology, 29, 450-60. 

Doetsch, F., Caille, I., Lim, D.A., Garcia-Verdugo, J.M., Alvarez-Buylla, A. (1999). Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell, 97, 703-16. 

Zhang, R.L., Zhang, Z.G., Zhang, L., Chopp, M. (2001). Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neurosci, 105, 33-41. 

This study reports the first isolation and characterization of neural progenitor and stem cells from the adult brain. Neural progenitor and stem cells were isolated from mouse striatal tissue containing the subventricular zone (a neurogeneic area of the adult brain) and cultured in vitro in the presence of epidermal growth factor. 

Subventricular Zone of the Inferior Horn of the Lateral Ventricle... 

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Lee MK, Rebhun LI, Frankfurter A (1990) Posdranslational modification of class III beta-tubulin. Proc Nati Acad Sci USA 87 7195-7199 Lendahl U, Zimmerman LB, McKay RD (1990) CNS stem cells express a new class of intermediate filament protein. Cell 60 585-595 Levison SW, Rothstein RP, Romanko MJ, Snyder MJ, Meyers RL, Vannucci SJ (2001) Hy-poxia/ischemia depletes the rat perinatal subventricular zone of oligodendrocyte progenitors and neural stem cells. Dev Neurosci 23 234-247... 

Lorente de No R (1934) Studies on the structure of the cerebral cortex. II. Continuation of the study of the Ammonic system. J Psychol Neurol 46 113-177 Love S, Barber R, Wilcock GK (1998) Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man. Neuroreport 9 955-959 Love S, Barber R, Wilcock GK (1999) Neuronal accumulation of poly(ADP-ribose) after brain ischaemia. Neuropathol Appl Neurobiol 25 98-103 Luskin MB (1993) Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone. Neuron 11 173-189 Magavi SS, Leavitt BR, Macklis JD (2000) Induction of neurogenesis in the neocortex of adult mice. Nature 405 951-955... 

Maslov AY, Barone TA, Plunkett RJ, Pruitt SC (2004) Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J Neurosci 24 1726 -1733... 

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