Adult neurogenesis

Figure 1. Functionality of adult neurogenesis. Adult neurogenesis occurs throughout adulthood. Hence, the physiological function(s) of adult neurogenesis is yet to be elucidated. Adult neurogenesis may be involved in the physiopathology of CNS functioning.

Imayoshi I, Sakamoto M, Ohtsuka T, Takao K, Miyakawa T, Yamaguchi M, Moii K, Ikeda T, Itohara S, Kageyama R (2008) Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain. Nat Neurosci 11 1153-1161 Imitola J (2007) Prospects for neural stem ceU-based therapies for neurological diseases. Neurotherapeutics 4 701-714... 

Palmer TD, WiUhoite AR, Gage FH (2000) Vascular niche for adult hippocampal neurogenesis. J Comp Neurol 425 479-494... 

Toth PT, Ren D, Miller RJ (2004) Regulation of CXCR4 receptor dimerization by the chemokine SDF-lalpha and the HIV-1 coat protein gpl20 a fluorescence resonance energy transfer (FRET) study. J Pharmacol Exp Ther 310 8-17 Tran PB, Miller RJ (2005) HIV-1, chemokines and neurogenesis. Neurotox Res 8 149-158 Tran PB, Ren D, Veldhouse TJ, Miller RJ (2004) Chemokine receptors are expressed widely by embryonic and adult neural progenitor cells. J Neurosci Res 76 20-34... 

Corotto R, Henegar J. and Maruniak J. (1994). Odor deprivation leads to reduced neurogenesis and reduced neuronal survival in the olfactory bulb of the adult mouse. Neuroscience 61, 739-744. 

Martinez-Marcos A., Ubeda-Banon I., Deng L. and Halpem M. (2000). Neurogenesis in the vomeronasal epithelium of adult rats evidence for different mechanisms for growth and neuronal turnover. Neurobiology 44, 423-435. 

The discovery of neurogenesis in certain areas (e.g., the hippocampus) of the adult brain represents a new departure from our conventional view of this organ... 

Jadad, A. R. (1998). Randomised Controlled Trials A User s Guide. London BMJ PublishingGroup. Kempermann, G. Kronenberg, G. (2003). Depressed new neurons Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression. Biol. Psychiatry, 54(5), 499-503. 

The total human complement of neurons is laid down around birth, and if they die they cannot be replaced - unlike most cells in our body. However, this central dogma of neuroscience has been challenged by the recent finding that neurogenesis can occur in the adult rat hippocampus, and these new cells seem to be required for at least one type of memory (Shors et al., 2001). Whether this will also be the case in... 

Shors TJ, Miesegaes G, Beylin A, Zhao M, Rydel T and Gould E (2001). Neurogenesis in the adult is involved in the formation of trace memories. Nature, 410, 372-376. 

In view of bcl-2 s major neuroprotective and neurotrophic roles, a study was undertaken to determine if lithium, administered at therapeutically relevant concentrations, affects neurogenesis in the adult rodent brain. To investigate the effects of chronic lithium on neurogenesis, mice were treated with therapeutic lithium (plasma levels 0.97 0.20 mM), for 4 weeks. After treatment with lithium for 14 days, the mice were administered single doses of BrdU (bromodeoxyuridine, a thymidine analog which is incorporated into the DNA of dividing cells) for 12 consecutive days. Lithium treatment continued throughout the duration of the... 

Anderson, M. F., Aberg, M. A., Nilsson, M. and Eriksson, P. S. Insulin-like growth factor-I and neurogenesis in the adult mammalian brain. Brain Res. Dev. Brain Res. 134 115-122, 2002. 

Alvarez Buylla, A. and Garcia Verdugo, J. M. Neurogenesis in adult subventricular zone. /. Neurosci. 22 629-634,2002. 

Lee, J., Duan, W. and Mattson, M. P. Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice. /. Neurochem. 82 1367-1375, 2000. 

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