Peripheral nerve damage

B, Thiamin Coenzyme in pyruvate and a-ketoglutarate, dehydrogenases, and transketolase poorly defined function in nerve conduction Peripheral nerve damage (beriberi) or central nervous system lesions (Wernicke-Korsakoff syndrome)... 

Phillips DE, Eroschenko VP. 1982. An electron microscopic study of chlordecone (Kepone) induced peripheral nerve damage in adult mice. Neurotoxicology 3(2) 155-161. 

Neuropathy. Some people infected with HIV will experience swelling of peripheral nerves. Damage to these nerves can cause burning or stinging sensations. 

There is a disease known as beriberi that causes weakness, fatigue, psychosis, gastrointestinal problems, peripheral nerve damage, brain damage, and ultimately death. Many years ago, this disease was particularly prevalent in rice-eating Asian societies that polished their rice. The polishings contain an essential human nutrient... 

Toxicity and health effects Prolonged periods of exposure to acrylamide through inhalation, skin absorption, and or eye contact cause irritation to the mucous membranes, the nose, and the eyes. Exposed workers also suffer from nausea, speech disorders, and weakness of legs and hands. It is a neurotoxin and disturbs the functions of the CNS, resulting in peripheral nerve damage. - ... 

B, Thiamin Coenzyme in pyruvate and Peripheral nerve damage... 

A review of serious complications included one case of cardiac tamponade (with full recovery of the patient after surgery), one case of peripheral nerve damage (foot drop with residual weakness after 6 years), and three cases of pneumothorax (all with full recovery) (90). 

Japanese Ministry of Health and Welfare. Information on adverse reactions to drugs. Peripheral nerve damage due to thiamphenicol. Jpn Med Gaz 1977 20 12. 

Adverse effects reported from nitrous oxide use have included nausea, vomiting, and headache. In addition, heavy chronic use has occasionally been reported to resemble the sort of dependence that develops with other depressant drugs. With hca y use come more severe problems, including numbness of the extremities and permanent peripheral nerve damage. There have also been some reports of death by asphyxiation after using large amounts in a poorly ventilated space (Walker Zacny, 2005). 

Signs seen with acute exposures can also be exhibited following repeated oral exposures to as little as 1 mg kg day of dinitrophenol. Repeated low-level exposures (2mgkg day ) can cause peripheral nerve damage. Dinitrophenols have been reported to cause cataracts (after repeated exposure). 

Petroleum ether (ligroin) consists primarily of n-pentane and -hexane. Therefore, the primary effects seen are on the CNS, including peripheral nerve damage and depression. 

Genes related to peripheral nervous system are to be investigated. Mechanisms of peripheral nerve damage in CIPN are not yet completely understood however, hints from preclinical animal models could be considered as a guidance. GWAS might also be helpful to identify new potential predictors of neuropathy development. 

Veronesi. B.,Arodentmodeloforganophosphateinduceddelayedneuropathy distribution of central (spinal cord) and peripheral nerve damage, Neuropathol. Appl. Neurobiol., 10, 357-368, 1984. 

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