Necking profiles

Since the spherical shape and the circular neck profile are assumed, the contact surface is the circle of the area jtx. Because of center-to center approach, the dielectric thickness 2h is a function of... 

In a further investigation, Coates and Ward determined the neck profiles for a range of linear polyethylenes of different molecular weight and morphology. The strain rate field can be defined by the change in strain rate for an incremental change in draw ratio. From equation (2) this is given by... 

Coates and Ward showed that neck profiles in tensile drawing which are determined by the strain rate field in the neck can be related to the strain hardening and strain rate sensitivity by Equation (12.44). This equation can be rewritten as... 

Coates, P.D. and Ward, I.M. (1980) Neck profiles in drawn linear polyethylene. 

Injection stretch blow molding processes use hollow preforms produced by injection molding. The preform is short and thick-walled relative to the finished blown article. The neck profile complete with screw thread is entirely formed by injection molding and is not modified by the blowing process. The other end of the preform is closed and typically dome shaped. 

The comparison of the APM expression profiling between primary and metastatic lesions demonstrated a higher frequency of aberrant APM component expression in metastasis suggesting that deficient APM component expression is associated with poor disease outcome (Marincola et al., 2000 Vitale et al, 2005). Indeed, these data were further strengthened in a study of our group using head and neck squamous cell carcinoma, where patients with low levels of APM components, in particular TAP and tapasin as well as MHC class I HC had a shorter survival than patients with high expression levels of these various components (Meissner et al, 2005). 

Plasma lipid profile. Tobacco was administered to 184 patients with head and neck cancer, 153 patients with oral precancerous conditions, and 52 controls. The treatment produced a significant decrease in plasma total cholesterol and ITDL cholesterol in patients with cancer and oral precancerous conditions, compared to controls. The plasma very low-density lipoproteins (VLDL)... 

Zhang, et al. Evaluation of carcinogen exposure in people who used reduced exposure tobacco products. J Natl Cancer Inst 2004 96(11) 844-852. NT002 Patel, P.S., M. H. Shah, F. P. ]ha, et al. Alterations in plasma lipid profile patterns in head and neck cancer and oral precancerous conditions. Indian J Cancer 2004 41(1) 25-31. 

Chung CH, Parker JS, Ely K et al. Gene expression profiles identify epithelial-to-mesenchymal transition and activation of nuclear factor-Kb signaling as characteristics of a high-risk head and neck squamous cell carcinoma. CuwcerRe 2006 66 8210-8218. 

Fluoropyrimidines (e.g., 5-FU, oral capecitabine) remain unchallenged as reference drugs for treating munerous solid tumors in adults, including digestive, head and neck, and breast cancers. The wide inter-patient variability observed in the pharmacokinetic profiles of these drugs is mainly caused by the erratic activity of dihydropyrimidine... 

The profile of the bottle shoulder and neck diameter are also important factors. The smaller the diameter of the closure and the more tapered the neck/shoulder, the more exaggerated the change in fill level becomes. Also, in order to create a 5-7% volume of ullage or vacuity the fill level height will be much lower, which can give the appearance of a short fill or deceptive volume. 

By using leukocytes from chemotherapy patients with squamous-cell carcinoma of the head and neck region, it was demonstrated that damage removal from DNA was related to cisplatin resistance [83], This type of study assumes the profile of adduct formation and repair to be the same in peripheral and tumor tissue. The hypothesis was supported by several early studies which employed either atomic absorption spectroscopy or immunochemical techniques to demonstrate a relationship between DNA adduct formation in blood cells and disease response [84-89]. Subsequent work revealed, however, that cisplatin-DNA adduct levels do not always correlate with survival [90] and can vary substantially between individuals [91]. 

The ideal parison with a constant wall thickness is not necessarily the optimum for BM. Even simple molded shapes encompass considerable variations in their profile. For example, the body of a bottle is much greater in diameter than the neck. For some containers, there may be... 

The dip BM process bears some resemblance to IBM in that it is a single-stage process performed with a preform on a core/blow pin.The difference is in the way the preform is made. The process uses an accumulator cylinder that is fed by an extruder. The cylinder has an injection ram at one end while the other is a free fit over the blow pin. The blow pin is dipped into the melt so that a neck mold on the pin seals the end of the accumulator cylinder. The injection ram is advanced to fill the neck mold then the blow pin is withdrawn at a controlled rate so that it is coated with a melt layer extruded through the annular gap between the pin and the accumulator cylinder. The thickness of the coating can be varied or profiled to an extent by varying the speed of the blow pin and the pressure on the injection ram. After trimming, the preform is BM in the same manner used for IBM. 

I told nysefrl was junping to concbsbns. Until a few mmutes ag) I d been convinced Carl Brenner was the kiler. But Mason fitted the profile just as wel And Brenner didrit keep the deconposing body of his gnndfether in the house. Or try to mask the smel with the same material that had been enbedded m a dead woman s neck. 

Arriola (8) and Ni (5) have observed a second mechanism for snap off in strongly constricted square capillaries. At low liquid flow rates, a bubble is trapped in the converging section of the constriction and liquid flows past the bubble. As liquid flow rate increases, waves developed in the film profile and at some critical liquid flow rate these oscillations become unstable and bubbles snap off. In these experiments, the bubble front is located upstream of the constriction neck. Therefore, no driving force for the drainage mechanism exists. Bubbles formed by this mechanism are produced at a high rate and have a radius on the order of the constriction neck. No attempt has previously been made to model snap-off rate by this mechanism in noncircular constrictions. 

The plasma concentration profiles can vary widely among different parenteral preparations of the same drug administered by intramuscular injection, even when the same injection site is used. Comparison of the plasma concentration profiles obtained after intramuscular injection in the lateral neck of ruminant calves of five different parenteral preparations of ampi-cillin at a similar dose level (7.7 l.Omg/kg) serves to illustrate the variation that can exist among preparations (Fig. 5). Estimation of the bioavailability of each preparation relative to a reference preparation... 

The drug concentration in a parenteral suspension can influence the plasma concentration profile. When different concentrations of amoxicillin (100 and 200mg/ml) in aqueous suspensions of amoxicillin trihydrate were administered intramuscularly at the same site and same dose level (lOmg/kg) to horses, the preparation of lower concentration (10%) provided relatively better absorption and a more consistent plasma concentration profile. Intramuscular injection of amoxicillin trihydrate (15% in a mixed oil base) in the neck (10 cm behind the ear) of pigs produced two peaks, 1.7 and 0.8pg/ml at 1.3 and 6.6 h, respectively, rather than a single peak in the plasma concentration profile and an eight-fold longer mean residence time of the antibiotic than a preparation of the same... 

---