Nausea oral ulcers

Rash (pruritic, erythematous, maculopapular, morbilliform), reduced/altered sense of taste (hypogeusia), G1 disturbances (anorexia, epigastric pain, nausea, vomiting, diarrhea), oral ulcers, glossitis Occasional... 

Diarrhea, abdominal pain, oral ulcers, cough, pruritus, myalgia, weight loss, nausea,... 

Zalcitabine NRTI1 0.75 mg tid3 Administer 1 h before or 2 h after an antacid Peripheral neuropathy oral ulcerations, pancreatitis, headache, nausea, rash, arthralgias Avoid concurrent cimetidine avoid concurrent neuropathic drugs (eg, ddl, zalcitabine, isoniazid). Do not administer with lamivudine... 

Causes neurotoxicity, autonomic and central nervous system toxicity, alopecia, mild leukopenia, mild anemia, and mild thrombocytopenia, as well as nausea, vomiting, diarrhea, constipation, stomatitis, and oral ulceration.3... 

FLUOROURACIL ANTIBIOTICS -METRONIDAZOLE t risk of toxic effects of fluorouracil (>27%), e.g. bone marrow suppression, oral ulceration, nausea and vomiting due to T plasma concentrations of fluorouracil Metronidazole i clearance of fluorouracil Avoid co-administration... 

D- icjtiriorrij CJri Nausea and vomiting hepatic toxicity with ascites diarrhoea severe local tissue damage and necrosis on extravasation anaphylactic reaction Scomatitis oral ulceration bone marrow depression alopecia folliculitis dermatitis in previously irradiated areas... 

Mijsiine (chlormethinc) Nausea and vomiting local reaction and phlebitis Bone marrow depression alopecia diarrhoea oral ulcers leukaemia amcnorrhoea sterility hyperu ricacmia teratogenic... 

Mild and transient gastrointestinal disorders, namely nausea, vomiting, diarrhea or anorexia, were observed in 30-40% of patients, and their severity is typically dose-related (20). Dryness or inflammation of the oropharynx, and moderate stomatitis were sometimes noted, but severe painful oral ulcers recurring after interferon alfa re-administration have been reported (241). More severe forms of digestive disease have been described in isolated case histories with microscopic colitis and the occurrence or the exacerbation of ulcerative colitis (SED-13, 1094) (SEDA-21, 372). 

Gastrointestinal adverse effects of tiopronin include nausea, vomiting, oral ulcers, and stomatitis (l-3,5,6). 

As a therapeutic agent, mechlorethamine has many toxic effects. Acutely, it causes nausea and vomiting, skin blistering, and ulceration. After a week or two, it causes leukopenia, lymphopenia, anemia, thrombocytopenia, diarrhea, oral ulcers, and hyperuricemia. It can cause sterility and after a few years, leukemia. The most susceptible tissues are those with renewable cell populations, bone marrow, lymphoid tissues, and gastrointestinal (GI) epithelium. The therapeutic dose of mechlorethamine and most of the cytotoxic chemotherapy drugs is very close to the toxic dose. The therapeutic index (ratio of beneficial effect to toxic effect) is small. 

Acetylcysteine should not be mixed with other medications and can cause nausea, vomiting, oral ulcers (stomatitis), and a mnny nose. Acetylcysteine is also an antidote for acetaminophen overdose if given within 12 to 24 hours after the overdose. 

A marked increase in fluorouracil toxicity was noted in 27 patients with metastatic colorectal cancer when they were given intravenous metronidazole 750 mg/m one hour before reeeiving intravenous fluorouracil 600 mg/m 5 days per week, every 4 weeks. Granuloeytopenia occurred in 74% of patients, nausea and vomiting in 48%, anaemia in 41%, stomatitis and oral ulceration in 34%, and thrombocytopenia in 19%. A pharmacokinetic study in 10 patients found that metronidazole reduced the clearance of fluorouracil by 27% over the 5-day period and increased the AUC by 34%. In vitro studies with human colon cancer cells failed to show any increased efficacy. ... 

The most common bisphosphonate adverse effects are nausea, abdominal pain, and dyspepsia. Esophageal, gastric, or duodenal irritation, perforation, ulceration, or bleeding may occur when administration directions are not followed or when bisphosphonates are prescribed for patients with contraindications. The most common adverse effects of IV bisphosphonates include fever, flu-like symptoms, and local injection-site reactions. Osteonecrosis of the jaw occurs rarely if it develops, oral chlorhexidine washes, systemic antibiotics, and systemic analgesics are used based on severity. 

Methotrexate, an antimetabolite, is indicated for moderate to severe psoriasis. It is particularly beneficial for psoriatic arthritis. It is also indicated for patients refractory to topical or UV therapy. Methotrexate can be administered orally, subcutaneously, or intramuscularly. The starting dose is 7.5 to 15 mg per week, increased incrementally by 2.5 mg every 2 to 4 weeks until response maximal doses are approximately 25 mg/wk. Adverse effects include nausea, vomiting, mucosal ulceration, stomatitis, malaise, headache, macrocytic anemia, and hepatic and pulmonary toxicity. Nausea and macrocytic anemia can be ameliorated by giving oral folic acid 1 to 5 mg/day. Methotrexate should be avoided in patients with active infections and in those with liver disease. It is contraindicated in pregnancy because it is teratogenic. 

Cold sodium thiomalate-. Pruritic dermatitis, stomatitis, marked by erythema, redness, shallow ulcers of oral mucous membranes, sore throat, and difficulty swallowing, diarrhea or loose stools, abdominal pain, nausea Occasional... 

It causes antiemetic action by blocking dopamine (D receptors and it also increases gastric motility. It is absorbed orally but bioavailability is 15% due to first pass metabolism. It is completely biotransformed and metabolites are excreted in urine. It is used in nausea and vomiting in postoperative period, drug induced, radiation, uraemia, hepatitis, peptic ulcer. It is also useful in reflex oesophagitis. 

Adverse effects include nausea, vomiting, diarrhoea, cholestasis, bone marrow depression, pancreatitis, oral and intestinal ulcers. Rarely hepatic necrosis. 

Toxicities In addition to nausea, vomiting, diarrhea, and alopecia, severe ulceration of the oral and Gl mucosa, bone marrow depression (with bolus injection), and anorexia are frequently encountered. A dermopathy (erythematous desquamation of the palms and soles) called the hand-foot syndrome is seen after extended infusions. 

Oral exposure [20, 82, 88, 89] Unpleasant taste, mouth ulceration, joint pain, gastrointestinal disturbance, skin rashes, fatigue, nausea and vomiting, itching and sore eyes... 

Relief of pain after surgery can be achieved with a variety of techniques. An epidural infusion of a mixture of local anaesthetic and opioid provides excellent pain relief after major surgery such as laparotomy. Parenteral morphine, given intermittently by a nurse or by a patient-controlled system, will also relieve moderate or severe pain but has the attendant risk of nausea, vomiting, sedation and respiratory depression. The addition of regular paracetamol and a NSAID, given orally or rectally, will provide additional pain relief and reduce the requirement for morphine. NSAIDs are contraindicated if there is a history of gastrointestinal ulceration of if renal blood flow is compromised. 

Methotrexate Nausea and vomiting diarrhoea fever anaphylaxis hepatic necrosis Oral and gastrointestinal ulceration, perforation may occur bone marrow depression hepatic toxicity including cirrhosis renal toxicity pulmonary infiltrates and fibrosis osteoporosis conjunctivFtis alopecia depigmentation menstrual dysfunction encephalopathy infertility lymphoma teratogenesis... 

Nephrotoxicity has been described during treatment with olsalazine (SEDA-21, 364). To assess the effects of 9 months of treatment with oral mesalazine 1.2 g/day and olsalazine 1 g/day on renal function, a randomized trial has been performed in 40 patients with ulcerative colitis in complete remission (91). Neither drug had a significant effect on glomerular filtration rate. Adverse effects (all mild to moderate) were more common in the mesalazine group they included abdominal pain and distension, dyspepsia, nausea, and diarrhea. 

Its adverse effects include restlessness, prolonged and forced expiration, nausea and vomiting, sweating, and skin reactions the last include rashes (2), occasionally oral lichenoid eruptions (3), and ulceration (4). Muscle twitching and mental disorientation can also occur in the elderly. With large doses, convulsions can occur (5). 

---