National Committee for Clinical Laboratory Standards

For a detailed discussion of the art of sample handling and data acquisition for blood gas measurements, see National Committee for Clinical Laboratory Standards. Blood gas pre-analytical considerations specimen collection, calibration, and controls Proposed Guideline. NCCLS publication C27-P, Villanova, Pennsylvania, NCCLS, 1985... 

NCCLS, National Committee for Clinical Laboratory Standards provides a medium for communication among professionals in healthcare, government, and industry in developing guidelines for clinical laboratory practices. 

NCCLS Infobase 99 (1999) NCCLS approved standards and guidelines. National Committee for Clinical Laboratory Standards, Wayne, PA. 

Institut de Recherches de la Siderurgie, France International Organization for Standardization ISO Council Committee on Reference Materials International Union for Pure and Applied Chemistry Laboratory of the Government Chemist, UK, formerly NPL National Bureau of Standards, USA, now NIST National Committee for Clinical Laboratory Standards, USA National Institute for Biological Standards and Control, UK Japanese National Institute for Environmental Studies National Institute of Occup. Health, Oslo, Norway National Institute of Standards and Technology, USA, formerly NBS,... 

NCCLS Document 1/L A 19-A. Primary reference preparations used to standardize calibration of immunochemical assays for serum prostate-specific antigen (PSA) Approved Guideline. NCCLS, Villanova, PA National Committee for Clinical Laboratory Standards (1996). 

National Committee for Clinical Laboratory Standards. 1995, Performance Standards for Antimicrobial Disk Susceptibility, 5th Edition, Approved standard. NCCLS Document M2-A5, Villanova, PA. 

National Committee for Clinical Laboratory Standards, 1996, Method for Broth Dilution Antifungal Susceptibility Testing Yeast Approved Standard, M27-A, 15, 10, NCCLS, VA Medical Center, Tucson, AZ. 

Procedures should be organized and indexed in the form of manuals and must be written in compliance with National Committee for Clinical Laboratory Standards (NCCLS) GP2-A2 (3). Technical procedures designed for use at the bench should be complete, easy to follow, and readily available to testing personnel. These procedures must contain the following information for each assay performed ... 

The study was performed in patients exposed to ionizing radiation after Chernobyl accident. Comparison groups included patients and healthy individuals exposed to the natural radiation levels. Control group included healthy volunteers who resided in Kyiv since Chernobyl accident Distribution by diagnosis is presented at table 1. Investigated persons were at the age of 43-72 (mean+SD for the exposed group 52,3 + 10,1 yrs for control group- 46,3 + 11,3 yrs). All studied persons participated by informed consent. Peripheral blood and bone marrow samples were obtained by a standard procedure (National. Committee for Clinical Laboratory Standards, 1991). Flow... 

National Committee for Clinical Laboratory Standards. Procedures for the collection of diagnostic blood specimen by venipuncture (H3-A3). Vanova, PA The National. Committee for Clinical Laboratory Standards 1991. 

The degree of resistance of the mutant clones to the relevant PRP may be assayed by a number of methods. The broth microdiluition susceptibility test, a reference method for determination of the Minimum Inhibitory Concentration (MIC), may be performed according to the guidelines of the National Committee for Clinical Laboratory Standard (NCCLS) as described (20). An example of the increase in the MIC values for Bac7(l-35) in mutagenized HB101 is shown in Table 1. Another suitable and simple method, here described, is the count of bacterial viable cells after incubation with the peptide. 

Standardized methods for surveillance of antifungal drug susceptibility have been a recent development (Rex et al, 1993). The M27 protocol of the National Committee for Clinical Laboratory Standards (NCCLS) for testing of yeasts focused on laboratory to laboratory reproducibility and became an approved standard in 1997 (National Committee for Clinical Laboratory Standards, 1997). A modification of M27 for testing of molds has recently been proposed as NCCLS document M38-P (National Committee for Clinical Laboratory Standards, 1998). With these tools, collaborative studies to validate the predictive power of these results have been possible. Interpretive breakpoints for... 

The hierarchy established among the different methods and materials suggests an easy organization (Tietz, 1979). However, serious practical problems have hampered fast progress. In the United States and in Europe, the National Committee for Clinical Laboratory Standards (NCCLS) and the European Committee for Clinical Laboratory Standards (ECCLS) have been founded. These standardization organizations promote the development and the ultimate use of reference materials and methods. The National Bureau of Standards (NBS) and the Centers for Disease Control (CDC) in the United States (Bayse, 1982), and the European Community Bureau of Beference (BCR) in Europe, undertake projects oriented more toward the preparation of certified reference materials (BCR, 1982). 

To resolve such confusion, several professional organizations have recommended water quality standards that are graduated according to classes of use. These specifications enable users to define their needs with more precision. Typical are those of the ASTM, the National Committee for Clinical Laboratory Standards (NCCLS), the College of American Pathologists (CAP), and the American Chemical Society (ACS). These specifications are summarized in Table 6-6. In general, laboratory water quality is defined in terms of its resistivity. The historical focus on resistivity as a measure of water quality presupposes that dissolved minerals are the main concern. Often it is true, but resistivity has been used as the major yardstick for water purity mainly because it has been the most easily measured. 

Regularly updated guidelines have been provided by the National Committee for Clinical Laboratory Standards (NCCLS) and are widely used in many countries, although the British Society for Antimicrobial Chemotherapy has produced its own guidelines and testing procedures (see Further reading section). 

National Committee for Chnical Laboratory Standards. The Reference System for the Clinical Laboratory Criteria for Development and Credentialing of Methods and Materials for Harmonization of Results Approved Guideline. NCCLS Document NRSCL13-A. Wayne, PA National Committee for Clinical Laboratory Standards, 2000. 

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