Biological Standards Act

The Biological Standards Act (1975) established the National Biological Standards Board. This Board, appointed by the UK health ministers and funded by the Health Department, is responsible for standards and control of biological substances, that is substances whose purity and potency cannot be adequately tested by chemical means, such as hormones, blood products and vaccines. The Board operates through the executive arm, the National Institute for Biological Standards and Control. 

The Biological Standards Act (1975) established the National Biological Standards Board. Appointed by the United Kingdom Health Ministers and... 

Under the terms of the Act, the TGA was created. It combined the old Therapeutics Division within the Department of Health with the National Biological Standards Laboratory. 

An internal standard method gives more reliable results when elaborate sample preparation is required, as in extraction of a drug substance from biological fluids, or extraction of pesticides and herbicides from soil and plant matter. The addition of internal standard (IS) to the sample and standard acts as a marker to give accurate values of the recovery of the desired compound(s). Since the determination of wt% involves the ratio of the detector responses in the two chromatograms, the injection volume is not critical as in an external standard method. 

Gatlin, L. A. Kinetics of a phase transition in a frozen solution. Developements in Biological Standardization, Vol. 74, p. 93-104. Acting Editors Joan C. May, F. Brown S. Karger AG, CH-4009 Basel (Switzerland), 1992... 

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