Nanoparticles peptide-conjugated

Diez I, Hahn H, Ikkala O, Bomer HG, Ras RHA (2010) Controlled growth of silver nanoparticle arrays guided by a self-assembled polymer-peptide conjugate. Soft Matter 6 3160-3162... 

Asai, T., et al. Cell-penetrating peptide-conjugated lipid nanoparticles for siRNA delivery. Biochemical and Biophysical Research Communications 444(4), 599-604 (2014)... 

G. Ruan et ah, Imaging and tracking of tat peptide-conjugated quantum dots in living cells new insights into nanoparticle uptake, intracellular transport, and vesicle shedding. /. Am. Chem. Soc., 129(47), 14759-14766 (2007). 

Li M, Tang Z, Zhang Y, Lv S, Li Q, Chen X. Targeted delivery of cisplatin by LHRH-peptide conjugated dextran nanoparticles suppresses breast cancer growth and metastasis. Acta Biomater. 2015 18 132-43. 

An arm-first method for the preparation of star-shaped block copolymers and peptide-conjugated polymer nanoparticles was reported by the Heise group. They used nitroxide-functionalized amines for NCA polymerization. The nitroxide... 

The conjugation of vitamin B12 has been shown to increase oral bioavailability of peptides, proteins, and particles.44 46 62,63 Russsell-Jones and coworkers have attempted to exploit RME of vitamin B12 for the enhanced intestinal uptake of macromolecules such as luteinizing hormone—releasing factor (LHRH), granulocyte colony-stimulating factor, erythropoietin, and a-interferon.44,46,63 Also, they demonstrated that surface modification of nanoparticles with vitamin B12 can increase their intestinal uptake.44,62 The extended applications of this unique transport system, however, appear partially hampered by its limited uptake capacity. In human being, the uptake of vitamin B12 is only 1 nmol per intestinal passage. 

Solid-Lipid Nanoparticles SLNs have been used to deliver small molecules and macromolecules such as DNA and peptides. The in vitro and in vivo applications of SLNs are reviewed elsewhere [125,126]. The stability and oral bioavailability of insulin were enhanced when administered in wheat germ agglutinin-conjugated nanoparticles [127], A polyoxyethylene stearate coat on the SLN confers stealth properties [128],... 

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