DNA-nanoparticle conjugates

In a recent report, 19- or 20-residue thiolated oligonucleotides were used in an exchange reaction with glutathione monolayer-protected gold clusters. After thiol substitution, the resulting DNA-nanoparticle conjugates can be separated by gel electrophoresis on the basis of the number of bound oligonucleotides and assembled with one another by DNA-DNA hybridization [151]. 

CuACC has also found important applications in the field of DNA nanotechnology [95]. For instance, Fishier et al. have reported the immobilization of azide-terminated gold nanoparticles to an alkyne-modified DNA, which led to the formation of a chain-like DNA-nanoparticle conjugates (Figure 10.32) [96]. 

---