Peptides LHRH

The study of hydrated biomolecules has only just begun and very few papers have been published on that topic [103-107]. Hydration enthalpies and entropies for the peptides LHRH and bradykinin [108] and for the protein BPTI [106,107] have been measured and the amount of water addition to folded vs unfolded states of cytochrome c has been studied [103-105]. At this point it is too early to draw general conclusions but it is already apparent that only a few water molecules can have significant structural consequences [107,108]. 

UK goserelin peptide Zoladex Synthetic small peptide LHRH agonist Hormone... 

In this chapter, we compare the iontophoretic transport of peptides (LHRH, neurotensin, vasopressin, calcitonin, and insulin) through electroporated and nonelectroporated skin. The results demonstrate enhanced transport of peptides following electroporation and a return to baseline values within a few hours after treatment. These results are consistent with an intrinsic alteration in skin transport properties due to electroporation. 

HPLC High Performance Liquid Chromatography LHRH Lutenizing Hormone Releasing Hormone PTC Phase transfer catalyst SPPS Solid Phase Peptide Synthesis TFA Trifluoro acetic acid... 

In LHRH, cleavage of the Glp peptide bond was a major reaction (Fig. 

M. F. Powell, L. M. Sanders, A. Rogerson, V. Si, Parenteral Peptide Formulations Chemical and Physical Properties of Native Luteinizing Hormone-Releasing Hormone (LHRH) and Hydrophobic Analogues in Aqueous Solution , Pharm. Res. 1991, 8, 1258 -1263 ... 

The vaginal route is eonsidered to be suitable for the loeal applieation and absorption of therapeuties like estrogens for hormone replaeement therapy or contraception. Systemic absorption of peptide drugs sueh as LHRH agonists and ealcitonin can also be achieved [65]. 

J. Rivier, C. Rivier, M. Perrin, J. Porter, and W. Vale, in LHRH Peptides as Male A Female Contraceptives, ed. G.l. Zatuchni, J.D. Shelton, J.J. Sciarra, Harper Row, Philadelphia (1981). 

Peptide/protein uptake rates across the nasal epithelia are dependent upon molecular mass. Relatively small peptides, such as oxytocin, desmopressin and LHRH analogues, cross relatively easily and several such products used medically are routinely delivered nasally. Larger molecules (of molecular mass greater than 10 kDa) generally do not cross the epithelial barrier without the concurrent administration of detergent-like uptake enhancers. Long-term use of enhancers is prohibited due to their damaging cellular effects. 

The synthesis and release of both FSH and LH from the pituitary is stimulated by a hypothalmic peptide, gonadotrophin-releasing hormone (GnRH, also known as gonadorelin, luteinizing hormone-releasing hormone (LHRH), or LH/FSH-releasing factor). 

Hormones Goserelin luteinizing hormone-releasing hormone (LHRH) deca peptide analogue Zoladex 1.3... 

---