Wound dressings nanofibres

An ideal scaffold should possess excellent biocompatibility, controllable biodegradability and suitable mechanical characteristics. Several studies have shown that nanofibrous scaffolds can enhance cellular responses like cell adhesion and cell phenotype maintenance. Electrospun PCL nanofibrous scaffolds can be fabricated in the laboratory for the treatment of partial or full thickness skin defects. These nanofibrous wound dressings, due to their porosity and inherent properties might... 

Mary SA, Dev VRG. Electrospun herbal nanofibrous wound dressings for skin tissue engineering. J Text Inst 2015 106(8) 886—95. 

Therefore, electrospiiming is considered to he an ideal fabrication technique for wound dressings. Nanofibrous wound dressings with well-controlled nanofeatures mandatory for wound healing can be obtained through electrospinning (Ladd et al. 2008 Yang et al. 2009 Zahedi et al. 2009). 

Kim, G.H., Yoon, H. A direct-electrospiiming process by combined electric field and air-blowing system for nanofibrous wound-dressings. Appl. Phys. A 90, 389-394 (2008). doi 10.1007/S00339-007-4330-0... 

Kliil MS et al (2003) Electrospun nanofibrous polyurethane membrane as wound dressing. J Biomed Mater Res B Appl Biomater 67(2) 675-679... 

Nanofibres are valued for their ultrahigh specific surface areas (i.e., surface-to-volume or surface-to-mass values) and have been found potentially useM in many applications, such as wound dressing, selective separation, immobiUsalion of biologically or pharmacologically active agents and molecules and scaffold for tissue... 

Biomedical applications of nanofibres generally fall into three categories selected separation, wound dressing and tissue engineering. 

Polymeric nanofibres have found various applications in the biomedical field, such as use of nanofibrous affinity membranes in selective separation, functional wound dressings in wound care and scaffolding materials for tissue repair and regeneration. 

Chen, J.P., Chang, G.Y., Chen, J.K., 2008a. Electrospun collagen/chitosan nanofibrous membrane as wound dressing. Colloids and Surfaces a-Physicochemical and Engineering Aspects 313, 183-188. 

Ignatova, M., et al., 2009. Electrospun non-woven nanofibrous hybrid mats based on chitosan and PLA for wound-dressing applications. Macromolecular Bioscience 9 (1), 102—111. 

Zhou, Y.S., et al., 2008. Electrospun water-soluble carboxyethyl chitosan/poly(vinyl alcohol) nanofibrous membrane as potential wound dressing for skin regeneration. Biomacromolecules 9 (1), 349—354. 

In general, textiles used in wound-dressing products include fibres, nanofibres, filaments, yarns, and woven/knitted/non-woven and composite materials. 

Textile materials can be used in moist wound management as fibres themselves (advanced fibres such as alginate and chitosan fibres), or conventional/advanced fibres can be modified or coated with various substances such as honey or hydrogels to obtain special properties such as ultra-absorbency, drag release, etc. In general, textiles used in wound-dressing products come in all possible forms, including fibres, nanofibres, filaments, yarns, and woven/knitted/non-woven and composite materials. 

Zahedi, P., Rezaeian, I., Ranaei-Siadat, S.O., Jafari, S.H., Supaphol, P., 2010. A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polymers for Advanced Technologies 21 (2), 77—95. 

FIGURE 55.5 Schematic of the dual spinneret electrospinning apparatus. (Reprinted from Int. J. Pharm., 364(1), Thakur, R.A., Florek, C.A., Kohn, J., and Michniak, B.B., Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing, 87-93. Copyright 2008, with... 

Due to its ease of implementation, electrospinning has received a lot of attention as a technique to produce nanoflbres [83]. When the diameter of polymer fibre materials shrinks from the microscale to the submicro or nanoscale, several new characteristics appear, such as enhanced surface area-to-volume ratio and a superior mechanical performance [84]. Therefore, biopolymer nanofibrous mats show great potential to be used as particle filters, nanocomposite reinforcing fibres, protective clothing and in biomedical applications like wound dressings, sutures, tissue engineering scaffolds, implantable devices and drug delivery [83-85]. 

Nanofibrous mats are being explored as biomedical grafts and wound dressings. It has been found that cells can adhere to and proliferate into the mats with a great deal of success. Also, because of the extremely small size of the nanofibers, the potential exists for layering of different pol5miers with specific functionalities. 

The ability to promote proliferation of COS-1 fibroblast cells over this conductive scaffold was evaluated and these nanofibrous blends are suggested as tissue engineering scaffolds and showed promise as functional wound dressings that may eliminate deficiencies of currently available antimicrobial dressings. 

Development of a drug-loaded nanofibrous material with a slow-releasing antimicrobial agent has significant potential for use in medical devices such as wound dressings, catheter cuffs, repair mesh, prosthetic vascular grafts, sewing cuffs and the artificial heart, all of which have polyester components. 

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