N-CAM neural cell adhesion molecule

NAP-I, NAP-2 Neutrophilactivating peptides -1 and -2 NBT Nitro-blue tetrazolium NCI Non-collagen 1 N-CAM Neural cell adhesion molecule... 

Fig. 4.6(a) Migration of LHRH neurocrine cells prenatal transportation along the track of extra-bulbar VN axons (caudal branch). CB, cribriform plate FB, forebrain cell types, TAG-1, transient axonal surface glycoprotein and N-CAM, neural cell adhesion molecule (from Yoshida et al, 1995). 

FRT Fischer rat thyroid N-CAM neural cell adhesion molecule... 

Adhesion molecules such as LI, neural cell adhesion molecule (N-CAM) and N-cadherin promote axonal regeneration by homophilic interactions between axons and Schwann cell surfaces (see Ch. 7). The expression of p75 (low affinity NGF receptor, Ch. 27) is also increased at the Schwann cell surface after injury. Extracellular matrix molecules, such as tenascin and proteoglycans, increase the regenerative potential of damaged peripheral nerves by binding to integrins on the axonal surface. 

Martini R, Schachner M. 1988. Immunoelectron microscopic localization of neural cell adhesion molecules (LI, N-CAM, and myelin-associated glycoprotein) in regenerating adult mouse sciatic nerve. J CeU Biol 106 1735-1746. 

Persohn E, Schachner M. 1987. Immunoelectron microscopic localization of the neural cell adhesion molecules LI and N-CAM during postnatal development of the mouse cerebellum. J Cell Biol 105 569-576. 

Effects of oligosaccharides on the biological functions of proteins (15 examples). The capacity for homophilic binding of the neural cell adhesion molecule (N-CAM, Section 12.5.3) is modulated by the extension of its polysialic chains. The binding of a highly specific heparin pentasaccharide sequence to the protein antithrombin III converts it to a potent anticoagulant (Section 17.3). 

The main carrier of polysialic acid units is the neural cell adhesion molecule N-CAM [52]. In adult rat brain, the sodium channel glycoprotein has also been found to be a carrier of polysialic acid [53]. Owing to its identical structure with some bacterial polysaccharides, brain polysialic acid can be identified with the aid of antibodies directed against these polysaccharides (Fig. 9) [49]. Polysialic acid is an unusually weak immunogen, and the polysialic acid seems thus to give protection to the bacteria from immunological defence mechanisms [54]. 

Other neuroendocrine markers that are occasionally used to identify normal neuroendocrine lung cells and neoplastic neuroendocrine cells include neurofilaments,neural cell adhesion molecules (N-CAM),A77 and Leu7. The most frequent neuropeptides, neuroamines, and hormones found in neuroendocrine lung neoplasms are listed in Table 12.11. TTF-1 is found in a high percentage of small cell carcinomas, atypical carcinoids, and large cell neuroendocrine carcinomas, but in less than 50% of typical carcinoids. 

Kibbelaar RE, Moolenaar CEC, Michalides RJAM, et al. Expression of the embryonal neural cell adhesion molecule N-CAM in lung carcinoma Diagnostic usefulness of monoclonal antibody 735 for the distinction between small cell lung cancer and non-small cell lung cancer. J Pathol. 1989 159 23-28. 

Well-studied CAMs of the Ig-family in the nervous system are the neural cell adhesion molecule (N-CAM) and the neuron-glia cell adhesion molecule (LI or NILE). Both molecules are found on neurons and have been suggested to mediate neuron-glia interactions by heterophilic binding mechanisms. Currently, it is unknown whether astroglia express N-CAM and/or LI in vivo (Persohn and Schachner, 1987 Bartsch et al.,... 

Friedlander, D.R, Milev, P., Karthikeyan, L., Margolis, R.K., Margolis, R.U. and Grumet, M. (1994) The neuronal chondroitin sulfate proteoglycan neurocan binds to the neural cell adhesion molecules Ng-CAM/Ll/NILE and N-CAM, and inhibits neuronal adhesion and neurite outgrowth. J. Cell Biol. 125 669-680. 

Fogar P, Basso D, Pasquali C et al (1997) Neural cell adhesion molecule (N-CAM) in gastrointestinal neoplasias. Anticancer Res 17 1227-1230... 

Zuber C, Lackie PM, Catteiall WA, Roth J (1992) Polysialic acid is associated with sodium channels and the neural cell adhesion molecule N-CAM in adult rat brain. J Biol Chem 267 9965-9971... 

Nakata D, Troy FA II (2005) Degree of polymerization (DP) of polysialic acid (polySia) on neural cell adhesion molecules (N-CAMS) development and application of a new strategy to accurately determine the DP of polySia chains on N-CAMS. J Biol Chem 275 38305-38316... 

These spikes are required for the attachment of the virus to the surface of the host cell through specific interactions with a cell surface receptor. The exact nature of this receptor is still a matter of debate, although a number of candidates have been suggested, including the neural cell adhesion molecule N-CAM and the low-affinity nerve growth factor receptor p75NTR. As for most other enveloped viruses, it is likely that cell surface glycolipids, ... 

Lackie PM, Zuber C, Roth J. Polysialic acid of the neural cell adhesion molecule (N- CAM) is widely expressed during organogenesis in mesodermal and endodermal derivatives. Differentiation 1994 57 119-131. 

Phillips GR, Krushel LA, Crossin KL. Developmental expression of two rat sialyltransferases that modify the neural cell adhesion molecule, N-CAM. Mol Bruin Res. 1997 Dev. Brain Res. 102 143-155. 

Polysialylated neural cell adhesion molecules (N-CAMs)... 

---