Mustargen

Mechlorethamine Mustargen) is a cytotoxic alkylating agent. Topical application of freshly prepared aqueous solutions are used in patients with early stages of cutaneous T-cell lymphoma. A major disadvantage to the use of this drug is the rapid induction of allergic contact dermatitis in some patients. [Pg.494]

Mechlorethamine (nitrogen mustard Mustargen), a derivative of the war gas sulfur mustard, is considered to be the first modern anticancer drug. In the early 1940s it was discovered to be effective in the treatment of human lymphomas. [Pg.640]

Mechlorethamine Mustargen, nitrogen mustard Bronchogenic carcinoma chronic leukemia Hodgkin disease non-Hodgkin lymphomas blood disorders (leukopenia, thrombocytopenia] skin rashes/itching Blood disorders (anemia, leukopenia, thrombocytopenia] Gl distress (nausea, vomiting] CNS effects (headache, dizziness, convulsions] local irritation at injection site... [Pg.570]

MOPP Mechlorethamine (Mustargen), vincristine (Oncovin), procarbazine, prednisone Hodgkin Disease... [Pg.583]

This is present in mechlorethamine (Mustargen), which is used in patients with Hodgkin s disease and other lymphomas, usually in combination with other drugs, such as in MOPP therapy (mechlorethamine, Oncovin [vincristine], procarbazine, and prednisone). It may cause bone marrow depression. [Pg.112]

Caryolysine, Cloramin, Dichloren, Embichen, Erasol, Mustargen hydrochloride, Mustine hydrochloride, Nitrogranulogen. [Pg.345]

EMBICHIN ENT 25,294 HN2 MBA MECHLORETHAMINE N-METHYL-BIS-CHLORAETHYLAMIN (GERMAN) METHYLBIS(P-CHLOROETHYL)AMINE N-METHYL-BIS(p-CHLOROETHYL)AMINE N-METHYL-BIS(2-CHLOROETHYL)AMINE (MAK) N-METHYL-2,2 -DICHLORODIETHYLAMINE METHYLDI(2-CHLOROETHYL)AMINE N-METHYL-LOST MUSTARGEN MUSTINE MUTAGEN NITROGEN MUSTARD N-LOST (GERMAN) NSC-762 TL 146... [Pg.180]

Cytoxan - cyclophosphamide Mustargen - mechlorethamine Thioplex - thiotepa... [Pg.395]

HN-3 Tris(2-chloroethyl)amine 2-Chloro-N,N-bis(2-chloroethyl)ethanamine Trichlorotriethyla-mine Nitrogen mustard-3 Mechlorethamine Mustargen... [Pg.1825]

Trade names Mustargen Mustine Mustine Hydrochloride... [Pg.354]

Macocyn oxytetracydine mechlorethamine Mustargen, Mustine, Mustine Hydrochloride Boots... [Pg.662]

Mechlorethamine (nitrogen mustard H2N Mustargen) HD NHL Mycosis fungoides (topical)... [Pg.2307]

Mechlorethamine HCl (Mustargen) was formerly used primarily in the combination chemotherapy regimen MOPP (mechlorethamine, vincristine [Oncovin], procarbazine, and prednisone) in patients with Hodgkin s disease. It is given by intravenous bolus administration in doses of 6 mg/m on days 1 and 8 of the 28-day cycles of each course of treatment. It has been largely replaced by cyclophosphamide, melphalan, and other more stable alkylating agents. It also is used topically for treatment of cutaneous T-cell lymphoma as a solution that is rapidly mixed and applied to affected areas of skin. [Pg.405]

Mechlorethamine hydrochloride (Mustargen) and carmustine (bischloronitrosourea, BCNU, BICNU) are used topically to treat cutaneous T-cell lymphoma. Both can be applied as a solution or in ointment form. It is important to monitor complete blood counts and liver function tests because systemic absorption can cause bone marrow suppression and hepatitis. Other side effects include allergic contact dermatitis, irritant dermatitis, secondary cutaneous malignancies, and pigmentary changes. Carmustine also can cause erythema and posttreatment telangiectasias. [Pg.405]

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