Mutagenicity nitrogen mustards

EMBICHIN ENT 25,294 HN2 MBA MECHLORETHAMINE N-METHYL-BIS-CHLORAETHYLAMIN (GERMAN) METHYLBIS(P-CHLOROETHYL)AMINE N-METHYL-BIS(p-CHLOROETHYL)AMINE N-METHYL-BIS(2-CHLOROETHYL)AMINE (MAK) N-METHYL-2,2 -DICHLORODIETHYLAMINE METHYLDI(2-CHLOROETHYL)AMINE N-METHYL-LOST MUSTARGEN MUSTINE MUTAGEN NITROGEN MUSTARD N-LOST (GERMAN) NSC-762 TL 146... 

The mutagenic effects of nitrogen mustard were discovered by Auerbach and Robson in 1940, but their results were not published until 1947 because of the war (Auerbach and Robson, 1947). Lotte Auerbach had been encouraged in the search for mutagenic chemicals by Muller, who felt that this was the road to directed mutation, as opposed to the essentially random nature of mutations induced by X-rays. Robson s role was to help in the handling of the mustard gas, but it seems... 

Mutagens affect DNA in different ways. Some mutagens, such as nitrogen mustard, bind to a base and cause it to make a different amino acid. These mutagens cause point mutations, because they change the genetic code at one point, so changing a protein s amino acid sequence. 

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