Cytotoxicity alkylating agents

CHaSO OfCHjUOSOjCHa. A cytotoxic alkylating agent used clinically to treat leukaemia. 

Carboxypeptidase G2 (CPG2, glutamate carboxypeptidase, EC 3.4.17.11) is a bacterial enzyme not produced in mammalian cells. It has been used with promising success to target cytotoxic alkylating agents to tumor cells [60][61]. In a series of studies, a CPG2 monoclonal antibody con-... 

Mechlorethamine Mustargen) is a cytotoxic alkylating agent. Topical application of freshly prepared aqueous solutions are used in patients with early stages of cutaneous T-cell lymphoma. A major disadvantage to the use of this drug is the rapid induction of allergic contact dermatitis in some patients. 

G.P. Wheeler, Studies related to the mechanisms of action of cytotoxic alkylating agent a review, Cancer Res., 22, 651-688 (1962). 

Cytotoxic alkylating agents consisting of benzimidazolecarbmate derivatives, (VII), prepared by Quada (5) were effective against colon and melanoma tumor cells. 

B. Vesicants (blister agents). Nitrogen and sulfur mustards and Lewisite are cytotoxic alkylating agents Lewisite combines with thiol moieties in many enzymes and also contains trivalent arsenic. 

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