Active ADP-ribosyltransferase

NO, in large amounts, also causes the autoribosylation of glyceralde-hyde-3-phosphate dehydrogenase, which inactivates this glycolytic enzyme (Dimmeler et al.,1992). Moreover, NO activates ADP-ribosyltransferases, this process being enhanced by previous nitrosylation of the enzyme by NO (Briine and Lapetina, 1989 Dimmeler et al., 1992). This pathway may be involved in the NO-mediated neurotoxic actions (Zhang et al., 1994). 

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