Multianalyte

The demand for mass-producible, low-cost diagnostic chips has had a significant impact on the development trends for optical sensor platforms. Arguably the most important characteristics of recent systems are the integration of multiple functionalities onto a single platform, the ability to perform multianalyte detection and the production of low-cost sensor platforms. These strategies are intended to maximise the viability of a device for development as a commercial product. 

The combination of pin printing and sol-gel processing techniques provides a simple method to rapidly fabricate reusable chemical sensor element into arrays that exhibit good analytical figures of merit. This methodology also provides a straightforward means to fabricate reusable sensor arrays for simultaneous multianalyte quantification. 

Cho E., Bridht F., Pin-printed chemical sensor arrays for simultaneous multianalyte quantification, Anal. Chem. 2002 74 1462-1466. 

Anderson G.P., King K.D., Gaffney K.L., Johnson L.H., Multianalyte interrogation using the fiber optic biosensor, Biosens. Bioelectron. 2000 14 771-778. 

Moreno-Bondi M.C., Alarie J.P., Vo-Dinh T., Multianalyte analyses system using an antibody-based biochip, Anal. Bioanal. Chem. 2003 375 120-124. 

The analytical techniques proposed in the literature generally give reliable information on lipids present in the paint layer. However, the presence of lipid mixtures and of particular environmental conservation conditions may affect the lipid pattern to such an extent that their identification may be very difficult and sometimes erroneous. Thus, a multianalytical approach is recommended which integrates chromatographic data with techniques such as mapping based on Fourier transform infrared spectroscopy or SIM on cross-sections, in order to better understand the distribution of lipids in the various paint layers. 

Multianalyte immunosensor is highly advantageous for field applications. It allows several compounds in a single run to be determined, irrespective to the nature of the... 

M.A. Gonzalez-Martinez, R. Puchades, and A. Maquieira, Comparison of multianalyte immunosensor formats for on-line determination of organic compounds. Anal. Chem. 73, 4326-4332 (2001). 

S. Rodriguez-Mozaz, S. Reder, M. Lopez de Alda, G. Gauglitz, and D. Barcelo, Simultaneous multianalyte determination of estrone, isoproturon and atrazine in natural waters by the River ANAlyser (RIANA), an optical immunosensor. Biosens. Bioelectron. 19, 633-640 (2004). 

The problem of multianalyte analysis is of high importance in different methods of analytical chemistry. The measurements with sensor arrays are not an exception they are always complicated by multicomponent calibrations, as the number of these calibrations, even if defined in accordance with the modem principles of experimental design, increases exponentially with the increase in the number of analytes. 

Kampioti AA, da Cunha ACB, de Alda ML et al (2005) Fully automated multianalyte determination of different classes of pesticides, at picogram per litre levels in water, by online solid-phase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Anal Bioanal Chem 382 1815-1825... 

Perform multivariate spectral analysis to obtain selective multianalyte response... 

Multianalyte Sulfamethazine/ Penicillins Parallux IDEXX Laboratories Inc. http //www.idexx.com... 

E. J. Cho, Z. Tao, E. C. Tehan and F. V. Bright, Multianalyte pin-printed biosensor arrays based on protein-doped xerogels, Anal. Chem., 2002, 74, 6177. 

Wadsak, M., Constantinides, I., Vittiglio, G., et al. (2000). Multianalytical study of patina formed on archaeological metal objects from Bliesbruck-Reinheim. Mikrochimica Acta 133 159-164. 

Multivariate IQC. Multivariate methods in IQC are still the subject of research and cannot be regarded as sufficiently established for inclusion in the guidelines. The current document regards multianalyte data as requiring a series of univariate IQC tests. Caution is necessary in the interpretation of this type of data to avoid inappropriately frequent rejection of data. 

Yuan M, Zhou W, Liu X et al (2008) A multianalyte chemosensor on a single molecule promising structure for an integrated logic gate. J Org Chem 73 5008-5014... 

Dye-doped polymeric beads are commonly employed in different formats (Fig. 5), namely as water-dispersible nanosensors, labels and in composite materials (DLR-referenced and multianalyte sensors, sensor arrays, magnetic materials, etc.). The sensing properties of the dye-doped beads are of little or no relevance in some more specific materials, e.g., the beads intended for photodynamic therapy (PDT). The different formats and applications of the beads will be discussed in more detail in the following section, and the relative examples of sensing materials will be given. 

S. E. Kakabakos, T. K. Christopoulos, and E. P. Diamandis, Multianalyte immunoassay based on spatially distinct fluorescent areas quantified by laser-excited solid-phase time-resolved fhiorometry, Clin. Chem. 38, 338-342(1992). 

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