Microvascular endothelium

Crone C, Olesen SP (1982) Electrical resistance of brain microvascular endothelium Brain Res 241 49-55... 

Youdim, K.A., McDonald, J., Kalt, W., and Joseph, J.A., Potential role of dietary flavonoids in reducing microvascular endothelium vulnerability to oxidative and inflammatory insults, J. Nutr. Biochem., 13, 282, 2002. 

Jackson, C. J, Garbett, P K., Nissen, B., and Schrieber, L (1990) Binding of human endothelium to Ulex europaeus I-coated Dynabeads. application to the isolation of microvascular endothelium J Cell Science 96,257—262. 

Pardridge, W.M., et al. 1993. Protamine-mediated transport of albumin into brain and other organs of the rat. Binding and endocytosis of protamine-albumin complex by microvascular endothelium. J Clin Invest 92 2224. 

Hie majority of substance exchange takes place in microvascular endothelium... 

N. Sinuonescu. Hie microvascular endothelium Segmental differentiation, tantscytosfc selective distribution of anionic sites. h Advances in Inflammation Research (G. Wftssmfln, B. Sunelson, and R. Padettl, eds,)r Raven Press, New Votk, 1979, pp. 61-70. 

G. E Pelade The microvascular endothelium. Revisited, In Endothelial Cell Biology n Health and Disease (N. Simionescu and M. SmuMHCu. eds,). Plenum Ptess. 

Palade GE, Simionescu M, Simionescu N. Structural aspects of the permeability of the microvascular endothelium. Acta Physiol Scand Suppl 1979 463 11-32. 

The arrest of tumor cells in the capillary bed of secondary organs and their subsequent extravasation occur through interactions with the local microvascular endothelium and the subendothelial matrix. The specificity of these interactions, depending on the heterogeneity of both microvascular endothelial cells (EC) and tumor cells, may favor in a selective way the initial adhesive events in preferred metastatic sites, and may consequently facilitate metastatic dissemination to those organs (Blood and Zetter, 1990 Pauli et al., 1990 Rusciano and Burger, 1992), similarly to what happens... 

Kem, P., Knedler, A. and Eckel, R. (1983). Isolation and culture of microvascular endothelium from human adipose tissue. J. Clin. Invest. 71, 1822-1829. 

Ryan, U., White, L., Lopez, M. and Ryan, J. (1982). Use of microcarriers to isolate and culture pulmonary microvascular endothelium. Tissue Cell 14, 597-606. 

Vorbrodt AW, Trowbridge RS (1991) Ultrastructural study of transcellular transport of native and cationized albumin in cultured sheep brain microvascular endothelium. 1 Neurocytol 20 998-1006. 

The FVB-T1E2/GFP mouse, in which the endothelium is fluorescent, has heen used to study morphological changes in the renal microvascular endothelium during ischemia-reperfusion injury in the kidney [169]. Alterations in the cytoskeleton of renal microvascular endothelial cells correlated with a permeability defect in the renal microvasculature as identified using fluorescent dextrans and two-photon intravital imaging. This study demonstrates that renal vascular endothelial injury occurs in ischemic AKI and may play an important role in the pathophysiology of ischemic AKI. 

Button TA, Mang HE, Campos SB, Sandoval RM, Yoder MC, Molitoris BA Injury ofthe renal microvascular endothelium alters barrier function after ischemia. American Journal of Physiology - Renal Fluid Electrolyte Physiology 285 F191-F198, 2003... 

Intra-renal arteriolar changes indistinguishable from nephrosclerosis are found, often in the absence of clinical hypertension [4]. The appearance of arteriolar nephrosclerosis before hypertension develops and the relatively short duration of hypertension before renal failure supervenes suggest that the initial renal injury from lead may be in the microvascular endothelium... 

Matis, W.L., Lavker, R.M. and Murphy, G.F. (1990). Substance P induces the expression of an endothelial-leukocyte adhesion molecule by microvascular endothelium. J. Invest. Dermatol. 94, 492-495. 

Anionic sites on the lumenal surface of pulmonary microvascular endothelium have been shown to bind cationic ferritin in isolated, perfused rat lung studies [196]. The cationic ferritin is taken up by vesicles and discharged into the capillary membrane. Similar anionic sites are also present on alveolar epithelial surfaces [25]. 

Grammas P, Martinez J, Miller B (2011) Cerebral microvascular endothelium and the pathogenesis of ncurodcgenerative diseases. Expert Rev Mol Med 13 el9. doi 10.1017/ S1462399411001918... 

F. Antohe, C. Heltianu, and N. Simionescu. Further evidence for the distribution and nature of histamine receptors on microvascular endothelium. Microcirc. Endoth. Lymph. 3 163-185 (1986). 

Tang DG, Diglio CA, Honn KV. Activation of microvascular endothelium by eicosanoid 12(S)hydroxyeicosatetraenoic acid leads to enhanced tumor cell adhesion via up-regula-tion of surface expression of alpha v beta 3 integrin a posttranscriptional, protein kinase C-and cytoskeleton-dependent process. Cancer Res. 54 (1994) 1119-1129. 

These findings suggest that the mechanisms of the antitumor and the antimetastatic actions of carp oil might involve the inhibition of DNA synthesis in LLC cells, and the inhibition of angiogenesis through the inhibition of LLC cell adherence to the microvascular endothelium. 

On the other hand, the inhibitory actions of oleic acid on metastasis in the liver and metastatic tumor growth in the liver, cannot be explained by the effects of DNA synthesis in LLC cells, and microvascular endothelial cells, or the adherence of LLC cells to the microvascular endothelium rather, these inhibitory actions by oleic acid are partly attributable to the inhibition of the angiogenesis induced by tumors. In conclusion, it seems likely that the antitumor and antimetastatic activities of carp oil may be partly ascribed to a fatty acid, oleic acid, as an active substance. However, the antitumor and antimetastatic effects of carp oil are insufficiently by themselves to explain the action of oleic acid. Further work is in progress to identify the active substance(s) in carp oil. 

Lehr Fl-A, Olofsson AM, Carew TE, Vajkoczy P, von Andrian UH, Flubner C, Bemdt MC, Steinberg D, Messmer K, Arfors KE P-selectin mediates the interaction of circulating leukocytes with platelets and microvascular endothelium in response to oxidized lipoprotein in vivo. Lab Invest 1994 71 380-386. 

Problems of leukocyte distribution in the microcirculation and their interaction with the microvascular endothelium have attracted considerable attention in recent years [17]. Leukocyte rolling along the walls of venules, but not arterioles, has been demonstrated. This effect results from differences in the microvascular endothelium, mainly attributed to the differential expression of adhesion molecules on the endothelial surface [24]. Platelet distribution in the lumen is important because of platelets role in blood coagulation. Detailed studies of platelet distribution in arterioles and venules show that the cross-sectional distribution of these disk-shaped blood elements is dependent on the blood flow rate and vessel hematocrit [25] molecular details of platelet-endothelium interactions are available [26]. Considerable progress has been made in computational modeling of leukocytes in microvessels and their interaction with red blood cells [27-29]. 

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