Antimetastatic activity

Antimetastatic activity Antimicrobial action Antimicrobial activity... 

A second family of carbohydrate-degrading enzymes, the lysozymes, produces synergistic antimetastatic activity when co-adrninistered with cisplatin [15663-27-1] to mice whose primary tumor had been surgically removed (51). 

The molecular details by which NAMI-A exerts antimetastatic effects in vivo have not been definitely determined, and may occur by multiple mechanisms. The solution chemistry of NAMI-A involves both loss of Cl and DMSO. Interestingly, the antimetastatic activity is retained under a wide variety of experimental conditions producing solvolyzed intermediates.192 The exact nature of the active species may be difficult to resolve. 

Prevention of Cancer Chemotherapy Drug-Induced Adverse Reaction, Antitumor and Antimetastatic Activities by Natural Products... 

Compounds 1 and 2, possessing antitumor and antimetastatic activities, were isolated from the methanol extract. Compounds 1 and 2 were identified as cassigarol A and piceatannol (3, 3 , 4, 5 -tetrahydroxy stilbene), respectively, based on the 1H-NMR spectral data and products... 

Experimental studies have also reported that aloe juice has antimetastatic activity and aloe extract inhibits induction of preneoplastic hepatocellular lesions. Antitumor effects of aloe extract may also depend on the ability to augment tumor-specific immunity. These findings have encouraged cancer treatment in humans with a preparation composed of aloe (5 years old) fresh leaf 300 g,... 

Claudio Nastruzzi was born in Ferrara, Italy, on March 29,1958. In 1983, he earned his undergraduate degree in pharmaceutical chemistry at the University of Ferrara, and in the late 1980s he was a fellow at the university s Department of Pharmaceutical Science, working on natural compound synthesis (prostaglandins and leukotrienes) and the characterization of isosazolic and isosazolinic nuclei reactivity. In 1988, he obtained his Ph.D. in pharmaceutical science with a dissertation on the synthesis and antitumor and antimetastatic activity of aromatic polyamidines. 

Bacac M, Hotze ACG, van der Schilden K, Haasnoot JG, Pacor S, Alessio E, Sava G, Reedijk J (2004) The hydrolysis of the anti-cancer ruthenium complex NAMI-A affects its DNA binding and antimetastatic activity an NMR evaluation. J Inorg Biochem 98 402-412... 

The potential antimetastatic activity of inhibitors of metalloproteinases has generated considerable work in the area as noted in the discussion of tanomastat (34). The very different stmcture of the inhibitor prinomastat (107) illustrates the considerable structural freedom that seems to exist for inhibitors of these enzymes. Displacement of halogen in 4-chloropyridine (99) by phenoxide leads to the diaryl ether (100). Reaction of intermediate 100 with chlorosulfonic acid affords the sulfonyl chloride (101). 

Incidentally, these particular iminosugars and alkaloids have been reported to exhibit a wide variety of anti-infective properties, anticancer and antimetastatic activities and immune modulatory functions (swainsonine), as will be mentioned in the following. 

This finding indicates that the antitumor and antimetastatic activities of royal jelly may be partly due to the direct inhibition of angiogenesis induced by solid tumors. This is the first report showing that royal jelly has an anti-angiogenic effect. 

The antitumor and antimetastatic activities of EPAD may be due to the combination of inhibition of DNA synthesis in LLC cells, increase of tumor apoptosis, inhibition of tumor-induced neovascularization, and activation of CD8 T cells however, the antitumor activity of EPA ethylester may be due to the combination of inhibition of DNA synthesis in LLC cells, an increase of tumor apoptosis, inhibition of tumor-induced neovascularization, and activation of NK cells. Thus, it is suggested that the mechanisms of the antitumor and/or antimetastatic actions of EPAD and EPA ethylester involve different immune functions, and the EPA ethylester dimer and EPA hydroxy ethylester may contribute to these actions. 

IL-12 has been shown in animal studies to have potent antitumor and antimetastatic activity, probably by its actions stimulating Thl cells and inducing IFNy production. 

Brunda MJ, Luistro L, Warrier RR, Wright RB, Hubbard BR, Murphy M, Wolf SF, Gately MK. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J Exp Med 1993 178 1223-1230. 

Kimoto M, Ando K, Koike S, Matsumoto T, Jibu T, Moriya H, Kanegasaki S. Significance of platelets in an antimetastatic activity of bacterial lipopolysaccharide. Clin Exp Metastasis. 11 (1993) 285-292. 

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