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Tight junctions proteins

Nakamuta S, Endo H, Higashi Y, Kousaka A, Yamada H, Yano M, Kido H (2008) Human immunodeficiency virus type 1 gpl20-mediated disruption of tight junction proteins by induction of proteasome-mediated degradation of zonula occludens-1 and -2 in human brain microvascular endothelial cells. J Neurovirol 14 186-195... [Pg.247]

Figure 11.2 Morphological differences between human alveolar epithelial cells in primary culture (A and C) and the A549 cell line (B and D). Cells are visualised by light microscopy (A and B) and immunofluorescence microscopy (C and D) using an antibody against a tight junctional protein, occludin. Figure 11.2 Morphological differences between human alveolar epithelial cells in primary culture (A and C) and the A549 cell line (B and D). Cells are visualised by light microscopy (A and B) and immunofluorescence microscopy (C and D) using an antibody against a tight junctional protein, occludin.
Gonzalez-Mariscal L, Betanzos A, Nava P, and Jaramillo BE [2003] Tight junction proteins. Prog Biophys Mol Biol 81 1 14... [Pg.362]

Nusrat A, Brown GT, Tom J, Drake A, Bui TTT, Quan C, and Mrsny RJ [2005] Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin. Mol Biol Cell 16 1725-1734... [Pg.362]

Yoo J, Nichols A, Mammen J, Calvo I, Song JC, Worrell RT, Matlin K, and Matthews JB [2003] Bryostatin-1 enhances barrier function in T84 epithelia through PKC-dependent regulation of tight junction proteins. Am J Physiol 285 C300-C309... [Pg.365]

Freshly isolated or subcultured brain microvascular endothelial cells offer a notable in vitro tool to study drug transport across the blood-brain barrier. Cells can be grown to monolayers on culture plates or permeable membrane supports. The cells retain the major characteristics of brain endothelial cells in vivo, such as the morphology, specific biochemical markers of the blood-brain barrier, and the intercellular tight junctional network. Examples of these markers are y-glutamyl transpeptidase, alkaline phosphatase, von-Willebrandt factor-related antigen, and ZO-1 tight junctional protein. The methods of... [Pg.406]

Another type of channel has been recognized quite recently. An ion channel, which regulates Mg2+ ion transport in kidney tubules, forms within the tight junctions that seal the extracellular space between cells (Fig. 1-15B). A protein paracellin forms channels through the tight junction protein complexes that surround the cells.614 615... [Pg.1782]

Hamm, S., et al. 2004. Astrocyte mediated modulation of blood-brain barrier permeability does not correlate with loss of tight junction proteins from the cellular contacts. Cell Tissue Res 315 157. [Pg.590]

Bolton, S.J., D.C. Anthony, and V.H. Perry. 1998. Loss of tight junction proteins occluding and zonula-occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo. Neuroscience 86 1245. [Pg.592]

Yirgintino, D., et al. 2004. Immunolocalisation of tight junction proteins in the adult and developing human brain. Histochem Cell Biol 122 51. [Pg.592]

Gumbiner, B., Lowenkopf, T., and Apatira, D. Identification of a 160-kDa polypeptide that binds to the tight junction protein ZO-1. Proc. Natl. Acad. Sci. USA. [Pg.71]

Laura RP, Ross S, Koeppen H, Lasky LA (2002) MAGI-1 A widely expressed, alternatively spliced tight junction protein. Exp Cell Res 275 155-170 Leung S-M, Ruiz WG, Apodaca G (2000) Sorting of membrane and fluid at the apical pole of polarized MDCK cells. Mol Biol Cell 11 2131-2150 Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Del Rev 23 3-25... [Pg.63]

E. coli strain Nissle 1917 Improves epithelial barrier function Increases tight junction protein expression, ZO-2 Zyrek et al. (2007)... [Pg.4]

Strengthening of epithelial tight junctions by increased expression of tight junction proteins, or by a combination of these mechanisms. [Pg.5]

Brain vascular endothelial cells are linked by tight junction proteins creating high-resistance junctions between cells that effectively prevent the movement of hydrophilic substances, including electrolytes, such as Na and K+. Water moves across the lipid bilayer of endothelial cells through simple diffusion and vesicular transport (Tait et al., 2008). However, specialized water channels are formed by molecules called aquaporins (AQPs), which are highly expressed in blood-brain interfaces to facilitate the transport of water across cell membranes. [Pg.127]


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See also in sourсe #XX -- [ Pg.159 ]




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Cytoplasmic tight junctional proteins

Tight junction

Tight junction proteins claudins

Tight junction proteins occludin

Tight junction proteins paracellular permeability

Transmembrane tight junction proteins

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