Microreactors technology

Jarosch, K., Tonkovich, A., Perry, S., Kuhlmann, D., and Wang, Y. (2005) Microreactor Technology and Process Intensification, in ACS Symposium Series, vol. 914, American Chemical Society, New York, pp. 258-273. 

Renken 2005 Hessel et al. 2005a, b Golb and Hessel 2004 Kockmann et al. 2006). Here, some concepts and recent developments relevant to synthetic chemists will be summarized. Microreactor technology is beginning to be used in the fine chemical and pharmaceutical industries (Hessel et al. 2005b), and several success stories have been reported already (Thayer 2005 Rouhi 2004). 

Before microreactor technology will be employed as a standard research tool, it will have to become more readily available commercially. Eventually, cheap, easy-to-use, flexible microreactors will be used as a valuable alternative to the round-bottomed flask. 

Chambers RD, Fox MA, Sandford G (2005) Elemental fluorine - Part 18. Selective Direct Fluorination of 1,3-Ketoesters and 1,3-Diketones using Gas/ Liquid Microreactor Technology. Lab Chip 5 1132-1139 Cheng RP, Gellman SH, DeGrado WF (2001) Beta-Peptides From Structure to Function. Chem Rev 101 3219-3232... 

Microreactor technology, application in combinatorial chemistry, 7 401, 422 Micro RNAs (miRNA), 17 620-621 Micro-routing, in waste collection, 25 869 Microsampling methods, in infrared spectroscopy, 14 232-233 Microscale microbial cultures, shaken, 16 406... 

Review of Developments in Portable Hydrogen Production Using Microreactor Technology Jamelyn D. Holladay, Yong Wang, and Evan Jones pp 4767 - 4790 (Review) DOl 10.1021/cr020721b... 

Portable Hydrogen Production Using Microreactor Technology... 

Microreactor Technology as an Efficient Tool for Multicomponent Reactions... 

Microreactor technology also offers a contemporary way of conducting chemical reactions in a more sustainable fashion due to the miniaturization and increased safety, and also in a technically improved manner due to intensified process efficiency. This relatively new technology is implemented in novel and improved applications and is getting more and more used in chemical research. 

The combination of the benefits from the two approaches clearly presents an attractive reaction design, and this chapter presents an overview of the reported examples in which the microreactor technology and the multicomponent approach are combined, usually with dramatically improved results compared to those previously reported. 

In this way, the authors proved that microreactor technology is a useful tool in handling highly unstable intermediates in a way that is easy to control. The reactions were conducted using less harsh conditions (higher temperatures were possible due to the thermal efficiency of the system) and in short reaction times. 

W-Methyl-A/ -nitroso-p-toluenesulfonamide (MNTS) is an important precursor for the production of diazomethane. Diazomethane is then further converted to a range of useful molecules in the pharmaceutical and fine chemical industry [69]. Production of MNTS is a highly exothermic process and includes the presence of the extremely toxic materials. Stark et al. [70] have explored the application of microreactor technology for the production of this industrially valuable material, assuming that due to the efficient heat exchange and the closed system, microflow conditions provide a safer environment for these hazards. 

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