Micro-RNA

The antiviral state induced by different types of IFNs is mediated by various IFN-induced proteins. The best-known antiviral effectors produced as a result of IFN cascade induction are shown in Table 2. They include 2 -5 oligoadenylate synthetase (2 -5 OAS), double-stranded RNA activated protein kinase (PKR), and myxovirus (Mx) proteins. Additional effectors include RNA-specific adenosine deaminase 1 (ADARl), the 20-kDa ISG product (ISG20), ISG54 and ISG56, and IFN-stimulated micro RNAs (Pedersen et al. 2007). [Pg.211]

Microreactor technology, application in combinatorial chemistry, 7 401, 422 Micro RNAs (miRNA), 17 620-621 Micro-routing, in waste collection, 25 869 Microsampling methods, in infrared spectroscopy, 14 232-233 Microscale microbial cultures, shaken, 16 406... [Pg.585]

Calin GA, Dumitru CD, Shimizu M et al. Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16at 13ql4 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002 99 15524-15529. [Pg.54]

Meng F, Henson R, Lang M et al. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 2006 130 2113-2129. lorio MV, Ferracin M, Liu CG et al. MicroRNA gene expression deregulation in human breast cancer. [Pg.55]

Closely related to siRNAs are miRNAs, or micro RNAs. miRNAs are the same size as siRNAs, but miRNAs are single stranded. Like siRNAs, micro RNAs bind mRNAs and interfere with translational processes.4... [Pg.130]

Zeng, Y., E.J. Wagner, and B.R. Cullen. 2002. Both natural and designed micro RNAs can inhibit the expression of cognate mRNAs when expressed in human cells. Mol. Cell 9, 1327-1333. [Pg.167]

Keywords Amyloid beta peptides Brain tumor stem cells Caspase-3 Cyclin-dependent kinase Glioblastoma Micro RNA Pentraxin... [Pg.799]

Micro RNAs (miRNAs) Specific miRNA and mRNA Alterations in Human... [Pg.800]

Louis DN (2006) Molecular pathology of malignant gliomas. Annu Rev Pathol 1 97-117 Lukiw WJ (2004) Gene expression profiling in fetal, aged, and Alzheimer hippocampus a continuum of stress-related signaling. Neurochem Res 29 1287-1297 Lukiw WJ (2007) Micro-RNA speciation in fetal, adult and Alzheimer s disease hippocampus. NeuroReport 18 297-300... [Pg.819]

Nicoloso MS, Calin GA (2008) Micro RNA involvement in brain tumors from bench to bedside. Brain Pathol 18 122-129... [Pg.820]

Because of the importance of micro-RNAs in gene regulation in both plants and animals, there is a need for profiling their expression in biological samples (51). Multiplexed detection methods in solution and in solid phase have been developed (52). [Pg.566]

Fig. 20.32 Microscopic image of a pyroxene rock wet with a micro-RNA solution and then with Ag colloid. The micro-SERS spectrum of micro-RNA is shown below. Exciting line 785 run...

Long JM, Lahiri DK (2011) Current drug targets for modulating Alzheimer s amyloid precursor protein Role of specific micro-RNA species. Curr Med Chem 18 3314-3321... [Pg.527]

Micro RNA (miRN.A) is a class of small (about 21 nucleotides) noncoding RNAs that bind to complementary mRNA molecules and inhibit their translation,... [Pg.119]

Small interfering RNA (siRNA) is a class of small RNA molecules that bind to mRNA and facilitate its degradation. Micro RNA and small interfering RNA also provide scientists with powerful experimental tools for inhibiting the expression of specific genes in the cell. [Pg.119]

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