Current drugs Ltd

Iddb Investigational Drugs Database, Current Drugs Ltd., http //www.current-drugs.com/products/iddb (2003). 

Current Drug Metabolism, Bentham Science Publishers Ltd. 

Current Drug Targets Immune, Endocrine and Metabolic Disorders, Bentham Science Publishers Ltd. 

Drugs, such as bleomycin, aclacinomycin and deoxyspergualin, were discovered by the Umezawa group at the Institute of Microbial Chemistry in Japan and developed in collaboration with the NCI a number of the agents currently in advanced precUnical development at the NCI, such as UCN-01, and quinocarmycin and spicamycin analogs (Fig. 4), are the result of collaborations between Japanese companies, such as Kyowa Hakko Kogyo, Fujisawa Pharmaceutical Co. Ltd, and IQrin Brewery Ltd, and the NCI. ... 

With poly(PGA), a biodegradable polymer backbone is linked to drugs, used primarily as chemotherapy. Conjugates with pa-clitaxel (Cell Therapeutics Inc./Chugai Pharmaceutical Co. Ltd.) showed good results in pre-clinical studies when administered either alone or combined with radiation [37]. A number of clinical studies are also currently under way to determine efficacy against various types of solid tumor [38- 1],... 

One other drug, Sativex (GW Pharmaceuticals, London, England) is currently undergoing phase Ilb/ III trials in the USA for the treatment of patients with advanced cancer whose pain is not controlled with opioid medications. The trials were expected to be completed by the end of 2009, after which FDA approval will be sought by the manufacturer to market Sativex in the USA with its partner, Otsuka Pharmaceutical Co. Ltd. Sativex is an oral mucosal spray which delivers a mixture of A -THC and cannabidiol. Cannabidiol is one of the phyto-cannabinoids found in cannabis which has no psychoactivity itself, but reduces the psychoactive side effects of A -THC when... 

Current address Computer-Aided Drug Design, Argenta Discovery Ltd., do Aventis Pharma Ltd., Rainham Road South, Dagenham, Essex, RMIO 7XS, United Kingdom (Electronic mail david.clark argentadiscovery.com). 

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