Gene expression deregulation

Meng F, Henson R, Lang M et al. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 2006 130 2113-2129. lorio MV, Ferracin M, Liu CG et al. MicroRNA gene expression deregulation in human breast cancer. 

Since the discovery of the first histone demethylase in 2004, a number of demethy-lases have been identified and implicated in the control of gene expression programs and cell fate decisions. The cellular functions of histone demethylases are only beginning to be deciphered, but many of these enzymes have nevertheless been found to play biologically important roles. Histone demethylases are linked to the regulation of for example stem cell self-renewal, differentiation, proliferation and hormone-dependent responses. These processes are critical for development and cellular homeostasis and their deregulation is implicated in pathological disorders. 

N16. Nunez, G., London, L., Hockenbery, D., Alexander, M., McKearn, J. P., and Korsmeyer, S. J., Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines. J. Immunol. 144, 3602-3610 (1990). 

Der, C. ). (2002). Loss of transgelin in breast and colon tumors and in RIE-1 cells by Ras deregulation of gene expression through Raf-independent pathways. /. Biol. Chem. 277, 9790-9799. 

Landolph JR, Verma A, Ramnath J, and Clemens F (2002) Molecular biology of deregulated gene expression in transformed C3H/10T1/2 mouse embryo cell lines induced by specific insoluble carcinogenic nickel compounds. Environmental Health Perspectives 110(Suppl. 5) 845-850. 

Interaction of compounds with a toxicity target can result in a wide variety of in cell phenotypes (22). Deregulation of gene expression can result in inappropriate cell division (neoplasia, teratogenesis), apoptosis, and protein synthesis (e.g., peroxisome proliferation). Cell death can result from stimuli resulting in apoptosis, which has been defined as pro-... 

That deregulation in nitrate reductase gene expression could possibly have been due to a modified transcription rate for the nitrate reductase gene or a modified translation rate for nitrate reductase mRNA, or it could have been due to interference with nitrate reduction, which could have limited reduced N metabolites to low levels. Further studies are needed to examine these possibilities. 

Impact on Gene Expression and Deregulation of Cell Proliferation... 

The presence of chromosomal translocations is a consistent feature of many leukemia s, lymphomas, and certain solid tumors. At the genetic level, these events can either deregulate an intact gene by disruption or removal and replacement of the adjacent controlling elements, or create a new fusion gene that express the N-terminus of one protein fused to the C-terminus of another protein. 

---