Mexiletine

Benfurodil hemisuccinate Benzbromarone Mexiletine HCI Chloroacetonitrile Bendazac... [Pg.1621]

I b With shortening of action potential Lidocaine, Mexiletine, Tocainide, Phenytoin, Aprindine... [Pg.96]

Patients who do not obtain sufficient symptomatic relief from other treatments may use lidocaine, benzonatate, bupivacaine topically or mexiletine orally. [Pg.195]

Tanelian DL, Brose WG (1991) Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers lidocaine, carbamazepine, and mexiletine. Anesthesiology 74 949-951... [Pg.703]

Some cardiac arrhythmias result from many stimuli present in the myocardium. Some of these are weak or of low intensity but are still able to excite myocardial tissue Lidocaine, by raising the threshold of myocardial fibers, reduces the number of stimuli that will pass along these fibers and therefore decreases the pulse rate and corrects the arrhythmia Mexiletine (Mexitil) and tocadnide (Tonocard) are also antiarrhythmic drag s with actions similar to those of lidocaine... [Pg.369]

ADM INI STERI NG TOCAIN IDE AN D M EXILETIN E Tocainide and mexiletine are administered at 8-hour intervals and with food (or an antacid) to prevent gastrointestinal upset. In addition, administering tocainide with food may offer some protection gainst toxicity because the absoq> tion rate is slowed in the presence of food. [Pg.375]

These drug s are contraindicated in those with a known hypersensitivity to any component of the preparation. The topical anesthetics are used cautiously in patients receiving Class I antiarrhytiimic drug s such as tocainide and mexiletine because the toxic effects are additive and potentially synergistic. [Pg.611]

C3H3CIO 78-95-5) see Befunolol Benfurodil hemisuccinate Benzarone Mexiletine Ofloxacin Secnidazole Sertaconazole Zoraepirac chloroacetonitrile... [Pg.2322]

Podrid PJ, Kowey PR, Frishman WF[, et al. Comparative cost-effectiveness analysis of quinidine, procainamide and mexiletine. Am J Cardiol 1991 68 1662-7. [Pg.589]

Kemper CA, Kent G et al (1998) Mexiletine for HIV-infected patients with painful peripheral neuropathy a double-blind, placebo-controUed, crossover treatment trial. J Acquir Immune Defic Syndr Hum Retrovirol 19(4) 367-372... [Pg.80]

Kieburtz K, Simpson D et al (1998) A randomized trial of amitriptyline and mexiletine for painful neuropathy in HIV infection. AIDS Clinical Trial Group 242 Protocol Team. Neurology... [Pg.81]

Freitag, D.G., Foster, R.T., Coutts, R.T. et al. (1997) Stereoselective metabolism of rac-mexiletine by the fungus Cunninghamella echinulata yields the major human metabolites hydroxymethylmexiletine and p-hydroxymcx-iletine. Drug Metabolism and Disposition The Biological Fate of Chemicals, 25, 685-692. [Pg.226]

Mexiletine Dizziness, sedation, anxiety, confusion, paresthesia, tremor, ataxia, blurred vision, nausea, vomiting, anorexia, aggravation of underlying conduction disturbances or ventricular arrhythmias... [Pg.80]

Nakajima, M., Kohayashi, K., Shimada, N., Tokudome, S., Yamamoto, T. and Kuroiwa, Y. (1998) Involvement of CYP1A2 in mexiletine metabolism. British Journal of Clinical Pharmacology, 46 (1), 55-62. [Pg.232]

This report presents various methods developed primarily at our laboratory for chromatographic resolution of racemates of several pharmaceuticals (e.g., -blockers, NSAIDS, anta-acids, DL-amino acids, Bupropion, Baclofen, Etodolac, Carnitine, Mexiletine). Recently, we developed methods for establishing molecular dissymmetry and determining absolute configuration of diastereomers (and thus the enantiomers) of (/< .S )-Baclofcn, (/d.SJ-Bctaxolol with complimentary application of TLC, HPLC, H NMR, LCMS this ensured the success of diastereomeric synthesis and the reliability of enantioseparation. [Pg.32]

Mexiletine, naphthylethylamine, norephedrine, primaquine 0.1% HCIO4 pH 1.9/MeOH (85/15) 134... [Pg.474]

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