Mexiletine Lidocaine

I b With shortening of action potential Lidocaine, Mexiletine, Tocainide, Phenytoin, Aprindine... [Pg.96]

Mechanism - Structurally like lidocaine, mexiletine inhibits the inward sodium current, thus reducing the rate of rise of the action potential. Phase 0. Mexiletine decreases the effective refractory period (ERP) in Purkinje fibers. The decrease in ERP is of lesser magnitude than the decrease in action potential duration (APD), with a resulting increase in ERP/APD ratio. [Pg.453]

Lidocaine, mexiletine and tocainide block open or inactivated sodium channels. These drugs have a rapid rate of association with sodium channels. [Pg.180]

MEXILETINE LIDOCAINE Mexiletine t lidocaine levels (with cases of toxicity when lidocaine is given intravenously) Mexiletine displaces lidocaine from its tissue-binding sites it also seems to l its clearance but the exact mechanism is uncertain at present Watch for the early symptoms and signs of lidocaine toxicity (perioral paraesthesia, T muscle tone)... [Pg.22]

Na+ Anticonvulsant drugs Class I antiarrhythmics Diuretic drugs Local anesthetic drugs Carbamazepine, phenytoin, valproic acid lA Disopyramide, procainamide, quinidine IB Lidocaine, mexiletine, phenytoin, tocainide IC Encainide, flecainide, propafenone Amiloride Bupivacaine, cocaine, lidocaine, mepivacaine, tetracaine... [Pg.15]

Gass IB drugs are less state-dependent blockers of fast Na+ channels, and they decrease the APD. The uses for lidocaine, mexiletine, and tocainide are discussed, as are the metabolism and adverse effects of lidocaine. [Pg.95]

IB Decrease refractory period effect on Lidocaine, mexiletine,... [Pg.482]

D6 Amiodarone, cimetidine, quinidine, SSRIs Antidepressants, flecainide, lidocaine, mexiletine, opioids... [Pg.35]

Lidocaine, mexiletine, and tocainide slow conduction velocity in ischemic, depolarized ventricular cells but not in normal tissue. [Pg.134]

Lidocaine, mexiletine, and tocainide rarely cause typical local anesthetic toxicity (ie, CNS stimulation, including convulsions) cardiovascular depression (usually minor) and allergy (usually rashes but may extend to anaphylaxis). Tocainide may cause agranulocytosis. These drugs may also precipitate arrhythmias, but this is less common than with class lA drugs. Hyperkalemia increases cardiac toxicity. [Pg.136]

A) Adenosine Amiodarone Disopyramide Esmolol Flecainide Lidocaine Mexiletine Procainamide Quinidine Verapamil... [Pg.141]

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