Mexiletine Acetazolamide

Extracted acetazolamide, amitriptyline, chlordiazepoxide, chlorpromazine, desipramine, dextromethorphan, diphenhydramine, doxepin, encainide, fentanyl, flecainide, fluoxetine, flurazepam, haloperidol, hydroxyethylflurazepam, ibuprofen, imipramine, lidocaine, ma-protiline, methadone, methaqualone, mexiletine, norchlorimipramine, nordoxepin, norfluoxetine, nordiazepam, nortriptyline, norverapamil, pentazocine, promazine, propafenone, propoxyphene, propranolol, protriptyline, quinidine, temazepam, trazodone, tri-mipramine, verapamil... 

Although changes in urinary pH can affect the amount of mexiletine lost in the urine, the effect of diet or the concurrent use of alkalinisers (sodium bicarbonate, acetazolamide) or acidifiers (ammonium chloride etc.) on the plasma concentrations of mexiletine does not appear to be predictable. There appear to be no reports of adverse interactions but concurrent use should be monitored. The UK manufacturer of mexiletine recommends that the concomitant use of drugs that markedly acidify or alkalinise the urine should be avoided. ... 

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