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Paroxetine Mexiletine

Inhibitors codeine, encainide, flecainide, fluoxetine, haloperidol, hydrocodone, 4-methoxy-amphetamine, metoprolol, mexiletine, oxycodone, paroxetine, propafenone, propoxyphene, risperidone, selegiline (deprenyl), thioridazine, most tricyclic antidepressants, timolol Fluoxetine, haloperidol, paroxetine, quinidine... [Pg.355]

IMATINIB 1. ANTIARRHYTHMICS -flecainide, mexiletine, propafenone 2. ANTIDEPRESSANTS - fluoxetine, paroxetine, TCAs, trazodone, venlafaxine 3. ANTIPSYCHOTICS -clozapine, haloperidol, perphenazine, risperidone, thioridazine 4. BETA-BLOCKERS - metoprolol, propanolol, timolol 5. DONEPEZIL 6. METHAMPHETAMINE Imatinib may cause t plasma concentrations of these drugs, with a risk of toxic effects Inhibition of CYP2D6-mediated metabolism of these drugs Watch for early features of toxicity of these drugs... [Pg.312]

Fluvoxamine markedly increases the AUC of mexiletine by inhibiting CYP1A2. Fluoxetine and paroxetine might also be expected to interact, albeit by inhibiting CYP2D6, but sertraline is possibly unlikely to interact. [Pg.269]

Mexiletine is also metabolised by CYP2D6 (e.g. see Mexiletine + Propafenone , p.269). In an in vitro study using human liver microsomes, paroxetine, fluoxetine, and sertraline extensively inhibited the metabolism of mexiletine. Using a model to prediet in vivo interactions, it was suggested that both fluoxetine and paroxetine may interact with mexiletine to a clinically relevant extent, whereas sertraline is less likely to interact. ... [Pg.270]


See other pages where Paroxetine Mexiletine is mentioned: [Pg.1583]    [Pg.8]    [Pg.254]    [Pg.401]    [Pg.407]    [Pg.624]   
See also in sourсe #XX -- [ Pg.269 ]




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Mexiletine

Paroxetine

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