Bradycardia mexiletine

MEXILETINE ANTIARRHYTHMICS Risk of bradycardia and 1 BP however, mexiletine 1 the Q-T prolongation of other antiarrhyth-mics so is often beneficial Additive effect antiarrhythmics are all myocardial depressants Monitor PR, BP and ECG closely... [Pg.22]

MEXILETINE BETA-BLOCKERS Risk of bradycardia (occasionally severe), 1 BP and heart failure Additive negative inotropic and chronotropic effects. Also, mexiletine is known to inhibit CYP1 A2-mediated metabolism of propanolol Monitor PR, BP and ECG closely watch for development of heart failure... [Pg.24]

Mexiletine can have major hemodynamic effects in patients with pre-existing impairment of left ventricular dysfunction (21). Circulatory depression with bradycardia and hypotension have been reported (17,22,23). [Pg.2330]

Overdosage with mexiletine causes dizziness, drowsiness, nausea, hypotension, sinus bradycardia, paresthesia, seizures, intermittent left-bundle branch block, and temporary asystole. With massive overdoses, coma and respiratory arrest may occur (see also Eigure 84). [Pg.440]

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