Sotalol Mexiletine

Chezalvielguilbert, F., Davy, J.M., Poirier, J.M. and Weissenburger, J. (1995) Mexiletine antagonizes effects of sotalol on qt interval duration and its proarrhythmic effects in a canine model of torsade-de-pointes. Journal of the American Collie of Cardiology, 26, 787—792. 

Classes I, III, and IV all involve transmembrane ion channels Classes I and III involve Na+ channels. Class I compounds are designed to block cardiac Na channels in a voltage-dependent manner, similar to local anesthetics. Not surprisingly, many of these Class I agents are either local anesthetics or are structurally based on local anesthetics. Class I compounds include procainamide (7.15), disopyramide (7.16), amiodarone (7.17), lido-caine (7.5), tocainide (7.18), mexiletine (7.19), and flecainide (7.20). The majority of these compounds possess two or three of the fundamental structural building blocks found within local anesthetics. Propranolol (7.21) is the prototypic Class II agent. Class III compounds include molecules that block outward K channels, such as sotalol (7.22) and dofetilide (7.23), and molecules that enhance an inward Na current, such as... 

Mexiletine Procainamide Propafenone Quinidine Tocainide Sotalol... 

Acepromazine, acetophenazine, adiphenine, azacyclonol, barban, benzilonium, benzyl nicotinate, biperiden, clemastine, clomiphene, cyclothiazide, dextropropoxyphene, dichlorprop, dicophane, diperodon, diphem-anil, diphenidol, emepronium, etenzamide, fenpiprane, flurbiprofen, haloperidol, mepenzolate, methyl-piperidyl benzilate, mexiletine, nadolol, penfluridol, phenaglycodol, phenylbutazone (100°), phosalone, pimozide, pipazethate (100°— red), pipoxolan, pyrrobutamine, rotenone, sotalol (100°), sulindac, veratrine, zimeldine... 

Also analyzed acebutolol, acetaminophen, alprazolam, amphetamine, atenolol, betaxolol, brotizolam, caffeine, camazepam, captopril, chloroquine, clobazam, clomipramine, cloth-iapine, clotiazepam, cloxazolam, cocaine, codeine, diclofenac, dihydralazine, dihydrocodeine, dihydroergotamine, diphenhydramine, domperidone, doxepin, droperidol, ergota-mine, ethyl loflazepate, fenethylline, fluoxetine, flupentixol, flurazepam, furosemide, gliclazide, hydrochlorothiazide, hydroxyzine, ibuprofen, imipramine, ketazolam, loprazo-1am, lorazepam, lormetazepam, maprotUine, medazepam, mepyramine, methadone, methaqualone, methyldopa, methylphenidate, metoclopramide, metoprolol, mexiletine, mianserin, midazolam, minoxidil, morphine, nadolol, nitrazepam, oxprenolol, papaverine, pentazocine, phenprocoumon, phenylbutazone, pipamperone, piritramide, practolol, pra-zepam, prazosin, promazine, promethazine, propoxyphene, propranolol, prothipendyl, quinine, sotalol, sulpride, thioridazine, trazodone, triazolam, trimipramine, tripelennamine, lyramine, verapeunil, yohimbine... 

Josefsson, M. Carlsson, B. Norlander, B. Fast chromatographic separation of (-)-menthyl chlorofor-mate derivatives of some chiral drugs, with special reference to amlodipine, on porous graphitic carbon. Chromatographia, 1993, 37, 129-132 [derivatization chiral also amlodipine, mexiletine, propranolol, sotalol]... 

The concurrent use of mexiletine and beta blockers can be clinically useful Mexiletine may reduce the QT prolonging effects of sotalol... 

A sfudy in animals showed fhaf mexiletine reduced the QT prolonging effect of sotalol and reduced the risk of torsade de pointes. ... 

Chezalveil-Guilbert F, Davy J-M, Poirier J-M, Weissenburger J. Mexiletine anla mizes effects of sotalol on QT interval duration and its proarrh3dhmic effects in a canine model of torsade de pointes. J Am Coll Cardiol (1995) 26,787-92. 

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