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Mexiletine drug interactions

Glynn-Bamhart, A. M. et al., Effect of low-dose methotrexate on the disposition of glucocorticoids and theophylline, J. Allergy Clin. Immunol., 88(2) 180-186, 1991. Ueno, K. et al., Mechanism of interaction between theophylline and mexiletine. Drug Intell. Clin. Pharm., 25(7-8) 727-730, 1991. [Pg.229]

Kara Y, Nakajima M, Miyamoto K-I, Yokoi T. Inhibitory effects of psychotropic drugs on mexiletine metabolism in human liver microsomes prediction of in vivo drug interactions. Xe-nobiotica (2005) 35, 549-60. [Pg.270]

Drugs and chemicals are known to cause activated interaction. The depressant action of opioid drugs is enhanced by drugs acting on the central nervous system (CNS) such as alcohol, anesthetics, anxiolytics, hypnotics, tricyclic antidepressants, and antipsychotics. Concomitant administration of opioid analgesics and monoamine oxidase inhibitors (MAOIs) should be avoided, or extra care should be taken if such a therapy is inevitable. Fatal reactions are reported when treated along with selegiline. Interactions also are reported with cyclizine, cimetidine, mexiletine, cisapride, metoclopramide, or domperidone. [Pg.339]

Mexiletine is a class Ib antidysrhythmic drug, similar in action to lidocaine, but it can be given orally. Its adverse effects occur in up to 50% of patients (1) and withdrawal is often necessary (2). The most common adverse effects are on the cardiovascular and central nervous systems. The pharmacokinetics, clinical use, and adverse effects and interactions of mexiletine have been reviewed widely (3-8). [Pg.2329]

Interactions of mexiletine with other cardioactive drugs have been reviewed (48). The most important are beneficial interactions with beta-adrenoceptor antagonists, quinidine, and amiodarone in the suppression of ventricular tachydysrhythmias. During these interactions the... [Pg.2331]

Bigger JT Jr. The interaction of mexiletine with other cardiovascular drugs. Am Heart J 1984 107(5 Pt 2) 1079-85. [Pg.2333]

The UK manufacturer notes that it may be neeessary to reduce the dose of mexiletine when used concurrently with drugs causing inhibition of hepatic enzymes, in particular the cytochrome P450 isoenzymes CYP1A2 and CYP2D6, which is consistent with the proposed mechanism of the interaction. [Pg.270]

Although changes in urinary pH can affect the amount of mexiletine lost in the urine, the effect of diet or the concurrent use of alkalinisers (sodium bicarbonate, acetazolamide) or acidifiers (ammonium chloride etc.) on the plasma concentrations of mexiletine does not appear to be predictable. There appear to be no reports of adverse interactions but concurrent use should be monitored. The UK manufacturer of mexiletine recommends that the concomitant use of drugs that markedly acidify or alkalinise the urine should be avoided. ... [Pg.270]

Flecainide and mexiletine are predominantly or partly metabolised by CYP2D6 but there appear to be no clinical cases of interactions between these drugs and fluoxetine. However, fluoxetine does interact with propafenone , (p.275), which is also metabolised by CYP2D6 so it would seem prudent to be alert for increased and prolonged effects of these drugs if fluoxetine is added. [Pg.1227]


See other pages where Mexiletine drug interactions is mentioned: [Pg.481]    [Pg.220]    [Pg.446]    [Pg.178]    [Pg.164]    [Pg.2331]    [Pg.787]    [Pg.265]    [Pg.280]   
See also in sourсe #XX -- [ Pg.481 ]

See also in sourсe #XX -- [ Pg.147 ]

See also in sourсe #XX -- [ Pg.2029 ]




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Mexiletine

Mexiletine interaction

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