Murine mammary carcinoma

Murata R, Nishimura Y, Hiraoka M. An antiangiogenic agent (TNP-470) inhibited reoxygenation during fractionated radiotherapy of murine mammary carcinoma. Int J Rad Oncol Biol Phys 1997 37 1107-1113. 

Shibata, M.A., J. Morimoto, and Y. Otsuki, Suppression of murine mammary carcinoma growth and metastasis by HSVtk/GCV gene therapy using in vivo electroporation. Cancer Gene Ther, 2002. 9(1) 16-27. 

The value of A app is tumor-dependent. It varies from 3.1 xlO 8 cm2/cmH20/sec in Morris hepatoma 5123 (Swabb et al., 1974) to 1.8xl0-6cm2/cmH2O/sec in a murine mammary carcinoma (MCalV) (Netti et al., 2000). The variation is likely due to the difference in tumor lines rather than experimental methods, because the same methods have also been used to quantify A app in a human colon adenocarcinoma (LS174T) in three different studies and the data from these studies are nearly identical (Boucher et al., 1998 Netti et al., 2000 Znati, 1995). 

Although animal models can provide important information regarding the bioavailability and pharmacology of potential anticancer drugs in mammals, they are not always accurate predictors of activity against human tumor cells. In one report [27], the activity of a series of isomeric [l,2-bis(di-fluorophenyl)ethylenediamine]dichloroplatinum(II) compounds was evaluated in MXT murine mammary carcinomas in vivo the same compounds were also tested against several human cell lines in culture. The in vivo screen revealed a 2,6-difluoro-substituted compound to be the most active, whereas the 2,4-difluoro-substituted compound was most active against the human breast-cancer cell lines. It was concluded that the mouse mammary carcinoma is not an appropriate model for human breast cancers. Extreme caution must be employed when animal tumor results are used to predict activity in human tumors. 

Several groups have used this reaction in recent years to prepare biologically active molecules. Benzothiophene derivatives 93, prepared from Gewald products 92 in three steps via a palladium-mediated aromatization reaction, (Scheme 21) were tested for their antiproliferative activity and inhibition of tubulin polymerization [55]. Several compounds showed inhibitory effects against murine leukemia (L1210), murine mammary carcinoma (FM3A) and human T-lymphoblastoid (Molt/4 and GEM) cells. For most of the compounds, there was a positive... 

Juacaba, S. R, Horak, E., Price, J. E. and Tarin, D. (1989). Tumor cell dissemination patterns and metastasis of murine mammary carcinoma. Cancer Res. 49, 570-575. 

Inhibitory effects of tannins on the proliferation of murine leukemia cells (LI210/0), murine mammary carcinoma cells (FM3A) and human T-lymphocyte cells (Molt4/C8, CEM/0)... 

McGinn CJ, Miller EM, Lindstrom MJ, et al (1994) The role of cell cycle redistribution in radiosensitization implications regarding the mechanism of fluorodeoxyuridine radiosensitization. Int J Radiat Oncol Biol Phys 30 851-859 McGinn CJ, Shewach DS, Lawrence TS (1996) Radiosensitiz-ing nucleosides. J Natl Cancer Inst 88 1193-1203 Milas L, Hunter NR, Mason KA, et al (1994) Enhancement of tumor radioresponse of a murine mammary carcinoma by paclitaxel. Cancer Res 54 3506-3510 Milas L, Hunter NR, Mason KA, et al (1995) Role of reoxygenation in induction of enhancement of tumor radioresponse by paclitaxel. Cancer Res 55 3564-3568 Miller EM, Kinsella TJ (1992) Radiosensitization by fluorodeoxyuridine effects of thymidylate synthase inhibition and cell synchronization. Cancer Res 52 1687-1694 Miller SJ, Lavker RM, Sun TT (2005) Interpreting epithelial cancer biology in the context of stem cells tumor properties and therapeutic implications. Biochem Biophys Acta 1756 25-52... 

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