Metal complexes antitumor

In contrast to this view, but in analogy with the behavior of several antitumor metal complexes, some authors proposed that the DNA is the probable target for cytotoxic activity of organotin(IV) compounds. In this section we survey and compare the most important literature data published to date on this subject. 

Petering DH, Antholine WE, Saryan LA (1984) In Ottenbrite RM, Butter GB (eds) Metal Complexes as Antitumor Agents in Anticancer and Interferron Agents, Marcel Dekker, NY, p 203... 

Nonsymmetrical ligand substitution reactions also play an important role in a number of biological processes. One of these concerns the antitumor activity of platinum metal complexes, for which substitution processes involving DNA moieties are generally accepted to... 

Although there has heen a great deal of research concerning how platinum(II) complexes hind to biological molecules and the hkely mechanism of antitumor activity of these platinum-containing species, far less attention has heen paid to the properties of other metal complexes in this arena. Recent attention has fallen on cohalt(II)-Schiff hase complexes, as several have heen discovered to have promise as antiviral agents. A review of recent work has appeared elsewhere [64], so the topic will not he covered here however, in addition to focusing on recent developments, emphasis is placed on the introduction of the new head unit, 3,6-diformylpyridazine (13), into Schiff-hase macrocyclic electrochemistry. 

Pinacolone, o-(diphenylphosphino)benzoyl-coordination chemistry, 401 Piperidine, IV-hydroxy-metal complexes, 797 pA a values azole ligands, 77 Plant roots amino acids, 962 carboxylic acids, 962 Plastocyanin copper binding site, 557 copper(II) complexes, 772 copper(II) site in, 770 Platinum, dichlorobis(benzonitrile)-IR spectrum, 264 Platinum, cis-dichlorodianunine-antitumor activity, 34, 979 Platinum, ethylenebis(triphenylphosphine)-reactions with 5,6-dimethyl-2,l,3-benzothiadiazole, 194 Platinum blue formation, 265 Platinum complexes acetylacetone reactions, 380 amides, 491 amidines... 

The Mechanism of the Reduction of (ImH)[trans-RuCl4(dmso)(Im)i by Ascorbic Acid Antitumor activity of metal complexes is not restricted to those of Pt (II) cited earlier. Some recent reports of possible candidates for the purpose of functioning as substitutes for the Pt(II) range of complexes have included Pd(II)... 

Caruso F, Rossi M (2004) Antitumor titanium compounds and related metallocenes. In Sigel H (ed) Metal Complexes in Tumor Diagnosis and as Anticancer Agents. CRC Press, USA, pp 353-384... 

Mestroni G, Alessio E, Calligaris M, Attia WM, Quadrifoglio F, Cauci S, Sava G, Zorzet S, Pacor S (1989) Chemical, biological and antitumor properties of mthenium(II) complexes with dimethyl sulfoxide. In Alessio E, Clarke MJ (eds) Ruthenium and other non-platinum metal complexes in cancer chemotherapy. Springer-Verlag, Berlin, New York, pp 71-87... 

Murugkar, A. Padhye, S. Guha-Roy, S. Wagh, U. Metal complexes of Taxol precursor 1. Synthesis, characterization and antitumor activity of the copper complex of 10-deacetylbaccatin thiosemicarbazone. Inorg. Chem. Commun., 1999, 2 545-548. 

Mitomycin C forms a weak association with metal ions and these metal complexes undergo rearrangement to mitosenes in methanol (86JMC144). Complexes were also tested for antitumor activity (86JMC1760). 

Other transition metal complexes with cis dichloro ligands have been tested for antitumor activity. The palladium analog cis-[PdCl2(NH3)2] is inactive, prohahly due to the high kinetic lability of Pd(II) compared to Pt(II), and isomerization is facile this process is blocked in the chelated en complex, which is active (16). More inert metal ions such as Rh(III) and Ru(III) also have active analogs (Table VI), and it is likely that some ruthenium complexes will soon enter clinical trials (31-33). 

After the serendipitous discovery of the antitumor properties of cisplatin (m-diaminedichloro-platinum), much effort has been devoted to finding other anticancer metal agents, and several Sn, Ti, Zr, and Hf /3-diketonates have been proven to possess interesting biological activity. For example, budotitane ((EtO)2Ti(bzac)2) was the first non-Pt metal complex to reach clinical trials as a potential anticancer agent.11-15... 

Cisplatin (CDDP) is a well-known metal complex exhibiting a wide range of antitumor activity, however, its clinical use is limited due to its signifi-... 

Some applications in the biomedical field have been also envisaged for ionic liquid crystals. Transition metal complexes have potential antitumor activity, so metallomesogens could in principle be useful in the therapy for cancer [68],... 

Gokhale et al. [72] have synthesized a series of hydroxynaphthoquinone metal complexes as antitumor agents. The cytotoxic studies against the human breast cancer cell line MCF-7 revealed enhanced activities for the metal complexes. The highest activity is observed for the copper compound of lawsone, Fig. (12) (2-hydroxy-l,4-naphthoquinone). 

Schiff bases and their complexes with Cu ", Zn ", Ni and Sn " as potential antitumor agents, were used in the fluorimetric method for preliminary screening of antitumor agents (Lee etal. 1993). The method was based on the consistency of the in-vivo and in-vitro interactions of drugs with DNA. Studies of Schiff bases-metal complex interaction with DNA using a fluorescence probe [ethidium bromide (EthBr)-DNA system] identified the parallelism between binding constants and antineoplastic... 

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