Analogs activity

Pharmacology Stavudine is a synthetic thymidine nucleoside analog active against HIV. It inhibits the replication of HIV in human cells in vitro. 

E. Van Den Neste, S. Cardoen, F. Offner, F. Bontemps, Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies Fludarabine and cladribine (Review), Int. J. Oncol. 27 (2005) 1113-1124. 

The role of the pyridone ring as a pharmacophore in cardiotonic agents such as amrinone (25-6) has been noted earlier very analogous activity is obtained with compounds in which the heterocylic ring is replaced by a pyridazinone. The synthesis of the first of these agents, pimobendan (35-6), starts with the acylation of the amino group in nitro-aniline (35-2) with anisoyl chloride (35-1) to give amide (35-3). 

Fig. 7.2 (a) The prototypical time course of disease episodes in affective disorders (modified after [18]). Disease episodes are initially related to external stressors with increasing strength of the episodes (kindling) which then leads to autonomous progression (episode sensitization) with periodically occurring disease episode of increasing frequency up to ultra-rapid, chaotic mood fluctuations, (b) Analogous activity pattern of... 

Anastasi A, Erspamer V, Bucci M (1971) Isolation and structure of bombesin and alytesin, 2 analogous active peptides from skin of European amphibians Bombina and Alytes. Experientia 27 166-167... 

PACLITAXEL ANALOGS ACTIVE AGAINST NORMAL TUMOR CELLS... 

Catalysts obtained by treatment with sulfuric acid are usually more active than those obtained with ammonium sulfate treatment However, a recent study shows that the analogous activity is generated on S04/Zr02 by the kneading method with ammonium sulfate [60]. 

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