Antitumor complexes

Gonzalez-Vllchez et al. (169,170) have reported the first example of a Ru(IV) antitumor complex 31. 

Kostrhunova H, Florian J, Novakova O, Peacock AFA, Sadler PJ, Brabec V (2008) DNA interactions of monofunctional organometallic osmium(II) antitumor complexes in cell-free media. J Med Chem 51 3635-3643... 

Egger A, Arion VB, Reisner E, Cebrian-Losantos B, Shova S, Trettenhahn G, Keppler BK (2005) Reactions of Potent Antitumor Complex trans-[RuniCl4(indazole)2]- with a DNA-Relevant Nucleobase and Thioethers Insight into Biological Action. Inorg Chem 44 122-132... 

Computational Studies on Platinum Antitumor Complexes and Their Adducts with Nucleic-Acid Constituents... 

Molecular-orbital calculations performed on platinum antitumor complexes and related species, and force-field calculations carried out on their adducts with nucleic acids are reviewed. The aim of the author is to point out the methodological difficulties encountered in these calculations, and to comment on the (sometimes problematic) results which they have yielded. 

The aim of the present contribution is to critically review computational work related to platinum antitumor drugs, published prior to 1998. After a section devoted to molecular-orbital calculations on platinum antitumor complexes and related compounds, we address force-field calculations on platinum adducts with DNA constituents that have been used (mainly in combination with NMR spectroscopy) to evaluate the structure of the adduct. A brief outlook concludes this chapter. 

The hydrolysis profile of the bifunctional dinuclear platinum complex [ trans-PtCl( 5NH3)2 2(jr - NH2(CH2)6 NH2)f+ (l,l/t,t( = 6), 10, the prototype of a novel class of potential antitumor complexes, has recently been studied by using [ H, N] HSQC NMR spectroscopy [62]. The process of the hydrolysis is sketched in Scheme 5.2. An interesting finding is that the position of the... 

The pATa values for the 2 and 2" of the multinuclear platinum complexes 1,1/t,t ( = 6) and l,0,l/t,t,t ( = 6) are lower than that for w-[Pt(NH3)2 C1(H20)]+, and is also lower than the reported values for [Pt(dien)(H20)] and [Pt(NH3)3 (H20)] + (Table 5.2) [62,64]. It is inferred that the smaller extent of hydrolysis and lower pATa values (about 5.62) of the monoaqua chloro speeies eompared to eisplatin (6.41) will have a major influence on the differ-enees in the speeiation and reaetivity of these platinum antitumor complexes under biologieal eonditions. The lower pAfa value suggests that the monoaqua monochloro complex T, the major hydrolysis product of 1, will be mainly in the less reaetive hydroxo form 4 under physiological pH [62]. 

Lipinski, J. (1989). Electronic structure of plat-inum(ii) antitumor complexes and their interactions with nucleic acid bases. Part ii. Journal of Molecular Structure (Theochem), 201, 295. 

Konishi, M., K. Saito, K. Numata, T. Tsuno, K. Asama, H. Tsukiura, T. Naito, and H. Kawaguchi Tallysomycin, a New Antitumor Complex Related to Bleomycin. II. Structure Determination of Tallysomycin. J. Antibiot. 1977, 789. 

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