MCF-7 human breast cancer cell line

Hsu J-T, Ying C, Lan H-C. 1998. The effects of pesticides chlordane, dieldrin and endosulfan on the growth of human breast cancer cell lines MCF-7 and SK-BR-3. J Chinese Agri Chem Soc 36(6) 535-546. 

Lee ATC, Azimahtol HLP, Tan AN. Styrylpyrone derivatives (SPD) induces apopotosis in caspases-7-dependent manner in the human breast cancer cell line MCF-7. Cancer Cell Int 2003 3 1-8. 

Another peculiarity of the study is that the use of a biological system has allowed the authors to hypothesize a possible mechanism of action of the leachate as a mixture, hypothesis that could have been drafted on the basis of the only knowledge derived by chemical analysis. Researchers suggest that leachate inhibits cell proliferation at low doses probably inducing a reversible cell cycle arrest that becomes irreversible at high doses, probably due to leachate-induced oxidative stress. This activity is mainly due to the chemical compounds extracted in the aqueous phase. Similar effects were noticed by previous investigations on other human cells (human peripheral blood lymphocytes and a human breast cancer cell line, MCF-7) [31, 32], supporting the hypothesis that cells that survive the initial insult from leachate constituents maintains the potential to proliferate until the effects on cell metabolism lead to death. 

Brown, A.M.C., Jeltsch, J.M., Roberts, M. and Chambon, P. (1984). Activation of the PS2 gene transcription is a primary response to estrogen in human breast cancer cell line MCF-7, Proc. Natl. Acad. Sci. U.S.A., 81, 6344-6348. 

Diel, P., Olff, S., Schmidt, S. and Michna, FI. (2001). Molecular identification of potential selective estrogen receptor modulator (SERM) like properties of phytoestrogens in the human breast cancer cell line MCF-7, Planta Med., Aug, 67, 6, 510-514. 

Hsu, . C., Li-Chan, E. C. Y., and Jao, C. L. (2011). Antiproliferative activity of peptides prepared from enzymatic hydrolysates of tuna dark muscle on human breast cancer cell line MCF-7. Food Chem. 126, 617-622. 

Blom A, Ekman E, Johannisson A, et al. 1998. Effects of xenoestrogenic environmental pollutants on the proliferation ofa human breast cancer cell line (MCF-7). ArchEnviron ContamToxicol 34 306-310. 

Toward the above objectives, and also that of developing new methods for proteomic investigation, this laboratory has undertaken the identification of proteins whose abundances or primary structures are modified in drug-resistant strains of the human breast cancer cell line MCF-7. The parental cell line and several strains selected by exposure to different anti-cancer drugs were provided by K. H. Cowan (Eppley Cancer Center, University of Nebraska), P. Gutierrez and D. D. Ross, (Greenebaum Cancer Center, University of Maryland), and J. A. Moscow, (Department of Pediatrics, University of Kentucky). 

Bernardi, L. R., Biunno, f (2005). Protein profile changes in the human breast cancer cell line MCF-7 in response to SELIL gene induction. Proteomics 5, 2433-2442. 

The effect of various peptides and growth factors in small cell lung cancer cells has been reported by Bepler et al [121]. Four peptides isolated from completely different sources with structural similarities represent members of a new family of growth factors [121]. These peptides include 1) a 60 amino acid residue breast cancer- associated pS2 peptide isolated from human gastric juice and the culture media of the human breast cancer cell line MCF-7, 2) a 106 amino acid residue pancreatic spasmolytic polypeptide (PSP) isolated from porcine pancreas and 3) a 49 and 50 amino acid residue peptide predicted from a cyclic DNA isolated from the skin of frog, Xenopus laevis. 

Gokhale et al. [72] have synthesized a series of hydroxynaphthoquinone metal complexes as antitumor agents. The cytotoxic studies against the human breast cancer cell line MCF-7 revealed enhanced activities for the metal complexes. The highest activity is observed for the copper compound of lawsone, Fig. (12) (2-hydroxy-l,4-naphthoquinone). 

Yonezawa T, Katoh K, Obara Y. (2004) Existence of GPR40 functioning in a human breast cancer cell line, MCF-7. Biochem Biophys Res Commun 314 805-809. 

Gaube, R, S. Wolfl, L. Pusch, T.C. Kroll, and M. Hamburger. 2007. Gene expression profiling reveals effects of Cimicifuga racemosa (L.) Nutt, (black cohosh) on the estrogen receptor positive human breast cancer cell line MCF-7. BMC Pharmacol. 7(1) 11. 

A hydroethanolic extract of hops bound to estrogen receptors in the estrogen receptor (ER)-positive human breast cancer cell line MCF-7. The same extract did not bind to progesterone receptors in the human breast cancer cell line T-47D (Zava et al. 1998). The extract stimulated the proliferation of T-47D (ER positive) cells but had no effect on MDA486 (ER negative) cells (Zava et al. 1998). An extract of hops was shown to have growth-inhibitory activity on estrogen receptor-positive breast cancer cell lines MCF-7 and T-47D (Dixon-Shanies and Shaikh 1999). 

Page MJ, Field JK, Everett NP, Green CD (1983) Serum regulation of the estrogen responsiveness of the human breast cancer cell line MCF-7. Cancer Res 43 1244-1250... 

Of note, due to the high cytotoxicity against the human breast cancer cell lines MCF-7 and MDA-MB-231 with IC50 values <2pM, the possibility of an interaction of 31 with the estrogen receptor was also investigated [109]. The binding efficiency was very low and the hypothesis was dismissed. 

Patole, J. Padhye, S. Padhye, S. Newton, C. J. Anson, C. Powell, A. K. Synthesis, characterization and in vitro anticancer activities of semicarbazone and thiosemicarbazone derivatives of salicylaldehyde and their copper complexes against human breast cancer cell line MCF-7. Indian J. Chem., Sect. A 2004, 43A, 1654-1658. 

UV-induced polymer grafting Human breast cancer cell line (MCF-7) Acrylic acid grafted onto Si-H terminated porous silicon particles via UV irradiation generated a hydrophilic surface. MCF-7 cells took up the particles with no apparent morphological changes Wang etal. (2011)... 

Cyanidin, pelargonidin, and delphinidin also displayed antiproliferative activity in two estrogen-dependent human breast cancer cell lines (MCF-7 and BG-1), but not in the estrogen receptor-negative MDA-MB-231 cell line (Schmitt and Stopper 2001). Cyanidin and delphinidin contributed to the potent inhibitors of the epidermal growth-factor receptor and were found to inhibit the growth of human vulva carcinoma cell line A431 in vitro (Meiers et al. 2001). 

Kugawa, F., Ueno, A., Kawasaki, M. Aoki, M. (2004). Evaluation of Cell Death Caused by CDF (Cyclophosphamide, Doxorubicin, 5-Fluorouracil) Multi-drug administration in the human breast cancer cell line MCF-7, Biol. Pharm. Bull. 27(3), 392-398. 

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