Metabotropic

MNQXis also a metabotropic glutamate leceptoi ligand. [Pg.550]

ACPD (l-aminocyclopentane-l,3-dicarboxylic acid) is a selective agonist for metabotropic glutamate (mGlu)... [Pg.12]

Glutamate Receptors Ionotropic Glutamate Receptors Metabotropic Glutamate Receptors... [Pg.552]

Conn P, Pin J-P (1997) Pharmacology and functions of metabotropic glutamate receptors. Ann Rev Pharmacol Toxicol 37 205-237... [Pg.763]

Schoepp DD, Jane DE, Monn JA (1999) Pharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology 38 1431-1476... [Pg.763]

Kunishima N, Shimada Y, Tsuji Y et al (2000) Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407 971-977... [Pg.763]

For differentiation of G-protein-coupled receptor sub-types from subtypes permanently linked to ion channels (ligand-gated ion channels) the terms metabotropic versus ionotropic receptors, respectively, are used. Prime examples of metabotropic receptors are given by the lnGlu receptor family of G-protein-coupled glutamate receptors. [Pg.763]

Purinergic System. Figure 2 Schematic of sympathetic cotransmission. ATP and NA released from small granular vesicles (SGV) act on P2X and a-i receptors on smooth muscle, respectively. ATP acting on inotropic P2X receptors evokes excitatory junction potentials (EJPs), increase in intracellular calcium ([Ca2+]j) and fast contraction while occupation of metabotropic ar-adrenoceptors leads to production of inositol triphosphate (IP3), increase in [Ca2+]j and slow contraction. Neuropeptide Y (NPY) stored in large granular vesicles (LGV) acts after release both as a prejunctional inhibitory modulator of release of ATP and NA and as a postjunctional modulatory potentiator of the actions of ATP and NA. Soluble nucleotidases are released from nerve varicosities, and are also present as ectonucleotidases. (Reproduced from Burnstock G (2007) Neurotransmission, neuromodulation cotransmission. In Squire LR (ed) New encyclopaedia of neuroscience. Elsevier, The Netherlands (In Press), with permission from Elsevier). [Pg.1051]

Mesolimbic System/Reward System Metabolic Syndrome Metabotropic Glutamate Receptors Metabotropic Receptor Metalloprote(in)ases Methicillin-resistant Staphylococci iV-Methyl D-aspartate Receptors Methylating Agents... [Pg.1496]

Tse FW, Tse A, HiUe B, Horstmann H, Aimers W (1997) Local Ca + release from internal stores controls exocytosis in pituitary gonadotrophs. Neuron 18 121-132 Tu JC, Xiao B, Yuan JP, Lanahan AA, Leoffert K, Li M, Linden DJ, Worley PF (1998) Homer binds a novel proUne-rich motif and links group 1 metabotropic glutamate receptors with 1P3 receptors. Neuron 21 717-726... [Pg.299]

Metabotropic Those not directly linked to ion channels but initiating biochemical processes that mediate more long-term effects and modify the responsiveness of the neuron. With these the first messenger of synaptic transmission, the NT, activates a second messenger to effect the change in neuron excitability. They are normally associated with reduced membrance conductance and ion flux (unless secondary to... [Pg.14]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...