Metabotropic serotonin

Table 5.5 Metabotropic GABA(B)-, glutamate- and serotonin-receptors ...

HT1A-R, metabotropic 5-hydroxy-tryptamine (serotonin) receptor 5-HT1-R, metabotropic 5-hydroxy-tryptamine (serotonin) receptor 5HT2-R, metabotropic 5-hydroxy-tryptamine (serotonin) receptor 5HT3-R, ionotropic 5-hydroxytryptamine receptor... 

L. Haak et al.. Metabotropic glutamate receptor activation modulates kainate and serotonin calcium response in astrocytes. J. Neurosci.. 17 (1997) 1825-1837. 

Such immunohistochemical studies were performed for the angiotensin II receptor subtypes ATj and AT2 in rat adrenal gland [48] and in the heart of rabbits [57], for the metabotropic glutamate receptor in rat piriform cortex [58], for serotonin 5-HT2A and 5-HT3 receptors in inhibitory circuits of the primate cerebral cortex [59], and for the dopamine Dj and D2 as well as M4 muscarinic receptor in striatonigral neurons [60]. 

Neurotransmission Neuropeptide signaling (Orexin receptor, Canna-binoid receptor, NAALAD2, Neurotensin receptors, Serotonin receptors, GABA A receptors. Metabotropic Glutamate receptors. Folate Hydro-lasel) Depression, Alzheimer s, Anxiety, Schizophrenia, Obesity, Urogenital... 

Diffuse systems Diffuse systems are broadly distributed, with single cells frequently sending processes to many different areas. The axons are fine and branch repeatedly to form synapses with many cells. Axons commonly have periodic enlargements (varicosities) that contain transmitter vesicles. The transmitters in diffuse systems are often amines (norepinephrine. dopamine, serotonin) or peptides that commonly exert actions on metabotropic receptors. Drugs that affect these systems will often have marked effects on such CNS functions as attention, appetite, and emotional states. 

A decrease in conductance is associated with neuronal excitation. With the exception of dopamine, all of the neurotransmitters listed are able to cause excitation by this mechanism via their activation of specific receptors acetylcholine (M,), glutamate (metabotropic), norepinephrine (alpha and beta,), and serotonin (5-HT, ). The answer is (B). 

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