Metabotropic allosteric modulator, positive

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Lindsley CW, Wisnoski DD, Leister WH, O Brien JA, Lemi-are W, Williams DL Jr, Burno M, Sur C, Kinney GG, Petti-bone DJ, Miller PR, Smith S, Duggan ME, Hartman GD, Conn PJ, Huff JR. Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of V-(l,3-Diphenyl-lH-pyrazol-5-yl) benzamides that potentiate receptor function in vivo J. Med. Chem. 2004 47 5825. 

Metabotropic glutamate receptor 5 positive allosteric modulators CPPHA (N-(4-chloro-2-[(l,3-dioxo-l,3-dihydro-2H-isoindol-2-yl)methyl]phenyl)-2-hydroxybenzamide) NCFP(N-(4-chloro-2-((4-fluoro-l,3-dioxoisoindolin-2-yl)methyl)phenyl)- picolinamide)... 

Noetzel MJ, Gregory KJ, Vinson PN, Manka JT, Stauffer SR, Lindsley CW et al (2013) A novel metabotropic glutamate receptor 5 positive allosteric modulator acts at a unique site and confers stimulus bias to mGlu5 signaling. Mol Pharmacol 83 835-847... 

Pettibone, D. J., Tiller, P. R., Smith, S., Duggan, M. E., Hartman, G. D., Conn, P. J., and Huff, J. R. (2004). Discovery of the positive allosteric modulators of the metabotropic glutamate receptor subtype 5 from a series of N-(l,3-diphenyl-l-H-pyrazol-5-yl)benzamides that potentiate receptor function. J. Med. Chem. 47 5825-5828. 

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Galici R, Jones CK, Hemstapat K et al (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxio-lytic-like effects in mice. J Pharmacol Exp Ther 318 173-185... 

Niswender CM, Johnson KA, Weaver CD et al (2008) Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol 74 1345-1358... 

Williams R, Johnson KA, Gentry PR et al (2009) Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate receptor 4 (mGluR4). Bioorg Med Chem Lett 19 4967-4970... 

Williams DL Jr, Lindsley CW (2005) Discovery of positive allosteric modulators of metabotropic glutamate receptor subtype 5 (mGluR5). Curr Top Med Chem 5 825-846... 

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