Calcium-sensing receptor Metabotropic glutamate receptors

Gama, L Wilt, S. G., and Breitwieser, G. E. (2001) Heterodimerization of calcium sensing receptors with metabotropic glutamate receptors in neurons. J. Biol. Chem. 276, 39053-39059. 

For example, mice deficient in the mGluRl protein have severe problems with motor coordination and learning.681682 Metabotropic glutamate receptors may participate in calcium sensing and signaling.683 684... 

The CaR is expressed in many cells such as parathyroid cells and C cells in the thyroid gland. It is also expressed in the kidneys, osteoblasts, in the gastrointestinal mucosa, and hematopoietic cells in bone marrow. It has been found that CaR is expressed in different amounts on the cell face of many cell types and in diverse species. CaR is a member of the G protein-coupled receptor family with seven hydrophobic transmembrane helices in the plasma membrane. It has a large N-terminal domain with about 600 amino acids located in the extracellular environment and is essential for sensing extracellular calcium concentration. CaR has a large cytosolic C-terminal domain with about 200 amino acids that is subjected to phosphorylation. A dimeric structure has been proposed based on the known crystal structure of the metabotropic glutamate receptor type 1. 

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