Purinergic System

Purinergic System Adenosine Receptors Sterol Transporters... 

Vascular Endothelial Growth Factor Nitric Oxide Purinergic System... 

Purinergic System. Figure 2 Schematic of sympathetic cotransmission. ATP and NA released from small granular vesicles (SGV) act on P2X and a-i receptors on smooth muscle, respectively. ATP acting on inotropic P2X receptors evokes excitatory junction potentials (EJPs), increase in intracellular calcium ([Ca2+]j) and fast contraction while occupation of metabotropic ar-adrenoceptors leads to production of inositol triphosphate (IP3), increase in [Ca2+]j and slow contraction. Neuropeptide Y (NPY) stored in large granular vesicles (LGV) acts after release both as a prejunctional inhibitory modulator of release of ATP and NA and as a postjunctional modulatory potentiator of the actions of ATP and NA. Soluble nucleotidases are released from nerve varicosities, and are also present as ectonucleotidases. (Reproduced from Burnstock G (2007) Neurotransmission, neuromodulation cotransmission. In Squire LR (ed) New encyclopaedia of neuroscience. Elsevier, The Netherlands (In Press), with permission from Elsevier). 

Linden J. M. (1999). Purinergic systems. In Siegel GL, Agranoff BW, Albers RW, Fisher SK, Uhler MD, eds, Basic Neurochemistry Molecular, Cellular and Medical Aspects. Philadephia, PA Lippincott-Raven, 347-62. 

Trapido-Rosenthal H. G., Carr W. E. and Gleeson R. A. (1987) Biochemistry of an olfactory purinergic system dephosphorylation of excitatory nucleotides and uptake of adenosine. J. Neurochem 49, 1174-1182. 

Clozapine-induced neuroleptic malignant syndrome an interaction between dopaminergic and purinergic systems 121. 

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