Metabotropic glutamate receptors death

Dale, L. B., Bhattacharya, M., Anborgh, P. H., Murdoch, B., Bhatia, M., Nakanishi, S., and Ferguson, S. S. (2000) G protein-coupled receptor kinase-mediated desensitization of metabotropic glutamate receptor 1A protects against cell death. J. Biol. Chem. 275, 38213-38220. 

Allen JW, Vicini S, Faden AI (2001) Exacerbation of neuronal cell death by activation of group I metabotropic glutamate receptors role of NMD A receptors and arachidonic acid release. Exp Neurol 169 449-460... 

Vincent AM, TenBroeke M, Maiese K (1999) Metabotropic glutamate receptors prevent programmed cell death through the modulation of neuronal endonuclease activity and intracellular pH. Exp Neurol 155 79-94... 

Glutamic acid Most neurons in the brain are excited by glutamic acid. Subtypes of glutamate receptors include the NMDA (A-methyl-o-aspartate) receptor, which is blocked by phencyclidine (PCP) and ketamine. NMDA receptors appear to play a role in synaptic plasticity related to learning and memory. Excessive activation of NMDA receptors following neuronal injury may be responsible for cell death. Glutamate metabotropic receptor activation can result in G-protein-coupled activation of phospholipase C or inhibition of adenylyl cyclase. 

Pellt rini-Giampietro DE, Pen t metabotropic glutamate 1 receptor antagonists in models of ischemic neuronal death Time-course and mechanisms. Neuropharmacology 1999 38 1607-1619. 

---