Metabotropic glutamate receptor antagonists

Markou A (2007) Metabotropic glutamate receptor antagonists novel therapeutics for nicotine dependence and depression Biol Psychiatry 61 17-22 Markou A, Paterson NE (2001) The nicotinic antagonist methyUycaconitine has differential effects on nicotine self-administration and nicotine withdrawal in the rat. Nicotine Tob Res. 3 361-373 MarttUa K, Raattamaa H, Ahtee L (2006) Effects of chronic nicotine administration and its withdrawal on striatal FosB/DeltaFosB and c-Fos expression in rats and mice. Neuropharmacology 51 44-51... 

Slassi A, Van Wagenen B, Stormann TM et al (2002) Heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists. NPS Pharmaceuticals, Inc. WO/2002/ 068417... 

Chaki S, Yoshikawa R, Hirota S, et al (2004) MGS0039 a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity. Neuropharmacology 46 457-467... 

Zahn, P. K. and Brennan, T. J. Intrathecal metabotropic glutamate receptor antagonists do not decrease mechanical hyperalgesia in a rat model of postoperative pain, Anesth. Analg. 1998, 87, 1354-1359. 

INVOLVEMENT OF ENDOCANNABINOID SIGNALING IN THE NEUROPROTECTIVE EFFECTS OF SUBTYPE 1 METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS IN MODELS OF CEREBRAL... 

Muralikrishna Rao, A., Hatcher, J. F., and Dempsey, R. J. (2000). Neuroprotection by group I metabotropic glutamate receptor antagonists in forebrain ischemia of gerbil. Neurosci. Lett. 293, 1-4. 

In the laboratory of D. Ma, the asymmetric synthesis of several metabotropic glutamate receptor antagonists derived from a-alkylated phenylglycines was undertaken. The preparation of (S)-1-aminoindan-1,5-dicarboxylic acid (AIDA) started with the Perkin reaction of 3-bromobenzaldehyde and malonic acid. The resulting ( )-cinnamic acid derivative was hydrogenated and the following intramolecular Friedel-Crafts acylation afforded the corresponding indanone, which was then converted to (S)-AIDA. 

Yoshimizu, T. and Chaki, S. (2004) Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039. Biochemical and Biophysical Research Commununications, 315, 493 196. 

Karasawa, J., Shimazaki, T., Kawashima, N. and Chaki, S. (2005) AMPA receptor stimulation mediates the antidepressantplike effect of a group II metabotropic glutamate receptor antagonist. Brain Res. 1042 (1), 92- 98. 

Pelliciari, R., Marinozzi, M., Natalini, B., et al. (1996) Synthesis and pharmacological characterization of all sixteen stereoisomers of 2-(2 -carboxy-3 -phenylcyclopropyl)glycine. Focus on (25,l 5,2 5,3 5)-2-(2 -carboxy-3 -phcnylcyclopropyl)glycinc, a novel and selective group II metabotropic glutamate receptor antagonist. Journal of Medicinal Chemistry, 39, 2259-2269. 

Nakamura, M., Kawakita, Y., Yasuhara, A., et al. (2006) In vitro and in vivo evaluation of the metabolism and bioavailability of ester prodrugs of MGS0039 (3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid), a potent metabotropic glutamate receptor antagonist. Drug Metabolism and Disposition, 34, 369-374. 

Noeske,T., Sasse, B.C., Stark, H., Parsons, C.G., Weil, T. and Schneider, G. (2006) Predicting compound selectivity by self-organizing maps cross-activities of metabotropic glutamate receptor antagonists. ChemMedChem, 1, 1066-1068. 

Kohara A, Takahashi M, Yatsugi S et al (2008) Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models. Brain Res 1191 168-179... 

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