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Metabolic acidosis alcohol ingestion

Lactate levels in the blood increase, producing an acidosis. This condition can be caused by hypoxia or by alcohol ingestion. Lack of oxygen results in increased NADH levels, and more pyruvate than normal is converted to lactate. High NADH levels from alcohol metabolism cause pyruvate to be converted to lactate. [Pg.173]

A 55-year-old woman and a 34-year-old man ingested, with suicidal intent, an unknown amount of what was reported to have been formalin (Koppel et al. 1990). The female patient was found in a coma and admitted to the hospital with shock (systolic blood pressure 50 mm Hg), respiratory insufficiency, and metabolic acidosis. The male patient, who had a history of alcohol abuse, was also hospitalized with shock (systolic blood pressure 60 mm Hg), respiratory insufficiency, and metabolic acidosis. Both patients underwent hemodialysis and hemofiltration treatment. Analysis of the formaldehyde samples ingested by both patients showed no evidence that these products contained methanol, although it was expected to have been detected. A chemical-toxicological screening indicated that no drugs other than fonnaldehyde had been ingested neither methanol or ethanol were detected in blood samples. Three... [Pg.133]

Ethylene glycol, which is widely used as an antifreeze for automobile radiators, upon ingestion causes depression of the CNS, metabolic acidosis, and severe renal damage. Its oxidation in the body requires the action of alcohol dehydrogenase ... [Pg.96]

High anion gap metabolic acidosis may develop in many clinical settings, inclnding nncontrolled diabetes meUitns (see Chap. 72), alcohol intoxication (see Chaps. 37 and 65), and starvation (see Chap. 62). Toxic ingestions of methanol, ethylene glycol, and salicylates are also associated with high anion gap metabolic acidosis (see Chap. 10). The mechanisms responsible for the development of acidosis in these settings are diverse. [Pg.989]

Metabolism When alcohol-containing mouthwashes are abused as a so-called surrogate alcohol (i.e. they are ingested similar to alcoholic beverages by alcohol dependent persons), the ingestion of the phenolic compoxmds such as thymol and methyl salicylate may exceed acceptable daily intake levels. In heavy episodic drinking scenarios, the compotmds could exacerbate tiie effects of ethanol, especially by contributing to metabolic acidosis [85 ]. [Pg.343]

Methanol and Formate. - Methanol intoxication can result from both accidental and deliberate ingestion. The alcohol undergoes ADH-catalysed oxidation to formaldehyde, which is then rapidly metabolised to formic add, resulting in metabolic acidosis. [Pg.15]

Isopropyl alcohol is widely used as a solvent, an antiseptic, and a disinfectant and is commonly available in the home as a 70% solution (rubbing alcohol). It Is often ingested by alcoholics as a cheap substitute for liquor. Unlike the other common alcohol substitutes methanol and ethylene glycol, isopropyl alcohol is not metabolized to highly toxic organic acids and therefore does not produce a profound anion gap acidosis. Hospitals sometimes color isopropyl alcohol with blue dye to distinguish it from other clear liquids this has led abusers to refer to it as blue heaven. ... [Pg.234]

The metabolite produced from a drug or some other exogenous substance is often pharmacologically active. Such substances are referred to as active metabolites. In some cases, active metabolites are responsible for toxic effects which exceed that of the parent substance. Methanol, ethylene glycol, and DDE are examples of active toxic metabolites. Methanol (wood alcohol) can be ingested accidentally or intentionally. Methanol is metabolized similarly to ethanol, via a two-step oxidation to an aldehyde (formaldehyde) that is converted to an add (formic add). The acid causes toxic effects such as acidosis and Impaired cell respiration, while the penetration of methanol into the vitreous humor can lead to blurred vision emd blindness. [Pg.252]

H. Ethanol (20%) alleviates the effects of ethylene glycol ingestion and toxicosis by preventing its metabolism to acidic intermediates. CNS depression caused by ethylene glycol and its resultant acidosis may initially be increased by the alcohol, which is also a depressant... [Pg.67]


See other pages where Metabolic acidosis alcohol ingestion is mentioned: [Pg.35]    [Pg.133]    [Pg.175]    [Pg.400]    [Pg.69]    [Pg.502]    [Pg.502]    [Pg.458]    [Pg.1769]    [Pg.936]    [Pg.133]    [Pg.268]    [Pg.665]    [Pg.195]    [Pg.324]    [Pg.454]    [Pg.570]    [Pg.160]    [Pg.25]    [Pg.135]    [Pg.697]    [Pg.359]    [Pg.608]   
See also in sourсe #XX -- [ Pg.502 ]




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