Mammary tumorigenesis

Jung KJ, Wallig MA and Singletary KW. 2006. Purple grape juice inhibits 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary tumorigenesis and in vivo DMBA-DNA adduct formation. Cancer Lett 233 279-288. 

Mevissen, M., M. Haussler, A. Lerchi, and W. Loscher. 1998. Acceleration of mammary tumorigenesis by exposure of 7, 12-dimethylbenz[a] anthracene-treated female rats in a 50-Hz, 100-pT magnetic field replication study. Jour. Toxicol. Environ. Health 53A 401-418. 

Russo J, Gusterson BA, Rogers AE, Russo IH, Wellings SR, van Zwieten MJ (1990) Comparative study of human and rat mammary tumorigenesis. Lab Invest 62(3) 244-278... 

Five differenf combinations of psyllium and wheat bran, with comparative levels of wheaf bran fo psyllium of 12% and 0%, 8% and 2%, 6% and 3%, 4% and 4%, and 0% and 6%, were evaluated and compared for fheir effects on chemically induced mammary tumorigenesis in F344 rats (Cohen et ah, 1996). After 19 weeks on the treatment diets, rats on 1 1 (wheat bran/psyllium) had the lowest rate of mammary tumorigenesis, and rats on the other combined fiber diets or on the psyllium-alone diet had an intermediate rate of fumorigenesis. Rats on a diet with higher level... 

Clark, C. A., Gardiner, J., McBurney, M. 1., Anderson, S., Weatherspoon, L. J., Henry, D. N., and Hord, N. G. (2006). Effects of breakfast meal composition on second meal metabolic responses in adults with type 2 diabetes mellitus. Eur. J. Clin. Nutr. 60,1122-1129. Cohen, L. A., Zhao, Z., Zang, E. A., Wyrm, T. T., Simi, B., and Rivenson, A. (1996). Wheat bran and psyllium diets Effects on N-methylnitrosourea-induced mammary tumorigenesis in F344 rats. /. Natl. Cancer Inst. 88, 899-907. 

PO013 Cohen, L. A., Z. Zhao, E. A. Zhang, T. T. Wynn, B. Simi, and A. Rivenson. Wheat bran and psyllium diets effects on N-methylnitrosourea-induced mammary tumorigenesis in F344 rats. J Nat Cancer Inst 1996 88(13) 898-907. 

Hilakivi-Clarke L, Onojafe I, Raygada M et al. Prepubertal exposure to zearalenone or genistein reduces mammary tumorigenesis. Br. J. Cancer 80, 1682-1688, 1999. 

Olivo S. E. and Hilakivi-Clarke L. (2005). Opposing effects of prepubertal low- and high-fat n-3 polyunsaturated fatty acid diets on rat mammary tumorigenesis. Carcinogenesis 26 ... 

Webb M, Emberley ED, Lizardo M, Alowami S, Qing G, Alfia ar A, Snell-Curtis LJ, Niu Y, Civetta A, Myal Y, Shiu R, Murphy LC, Watson PH. 2005. Expression analysis of die mouse S 100A7/psoriasin gene in skin inflammation and mammary tumorigenesis. BMC Cancer 5 17. 

Chen, J., Tan, K.P., Ward, W.E., and Thompson, L.U. 2003. Exposure to flaxseed or its purified lignan during suckling inhibits chemically induced rat mammary tumorigenesis. Exp. Biol. Med 228, 951-958. 

Rickard, S.E., Yuan, Y.V., Chen, J., and Thompson, L.U. 1999. Dose effects of flaxseed and its lignan on N-methyl-N-nitrosourea-induced mammary tumorigenesis in rats. Nutr. Cancer 35, 50-57. 

Serraino, M. and Thompson, L.U. 1992. The effect of flaxseed supplementation on the initiation and promotional stages of mammary tumorigenesis. Nutr. Cancer 17, 153-159. 

Cohen, L.A., Zhao, Z., Pittman, B., and Khachik, F. 1999. Effect of dietary lycopene on N-methylnitrosourea-induced mammary tumorigenesis. Nutr. Cancer 34, 153-159. 

Stevens, J.T., C.B. Breckenridge, L.T. Wetzel, J.H. Gillis, and L.C. Luempert III (1994). Hypothesis for mammary tumorigenesis in SD rats exposed to certain triazine herbicides. J. Toxicol. Environ. Health, 43 139-153. 

Our finding that dietary fat could enhance mammary tumorigenesis in animals was not in fact a new observation. Beginning with the studies of Tannenbaum (6), a number of investigators had shown that animals fed high-fat diets develop mammary tumors more readily than those fed low-fat diets. Similar observations had also been made for skin tumors, but not all types of tumors show this association with... 

The exact mechanism of action is not known, but various possibilities have been suggested. Mammary tumorigenesis is clearly influenced by hormones, and high-fat diets may alter the hormonal pattern in ways that favor tumor growth (16,17). It seems less likely that a hormonal mechanism would be involved in effects of dietary fat... 

Another model often used in cancer research is the spontaneous or virally induced tumor. Mouse mammary tumorigenesis is characterized by the presence of preneoplastic hyperplastic alveolar nodules that arise from normal mammary gland cells to develop mammary adenocarcinomas (51) Female inbred C H/St mice infected with the" Bittner Milk Factor", a B-type ribonucleic tumor virus (52) or Murine Mammary Tumor Virus-S (MuMTV-S) develop mammary adenocarcinoma. Addition of 2 ug/ml of selenite in the drinking... 

Menendez, J.A., Ropero, S., Mehmi, I., Atlas, E., Colomer, R., and Lupu, R., Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-lrnolenic fatty acids a novel mechanism by which dietary fat can alter mammary tumorigenesis, Int. J. Oncol., 24, 1369, 2004. 

Inano, H., Onoda, M., Inafuku, N., Kubota, M., Kamada, Y., Osawa, T., Kobayashi, H. and Wakabayashi, K. (2000) Potent preventive action of curcumin on radiation-induced initiation of mammary tumorigenesis in rats. Carcinogenesis 12, 1 835-1 841. 

Mammary tumorigenesis was very sensitive to the level of linoleic acid in the diet and increased proportionally in the range of 0.5-4.4% at which the effect leveled off... 

Milk fat contains several compounds that have demonstrated anticancer activity in animal models. The more important ones are rumenic acid, a potent inhibitor of mammary tumorigenesis, sphingomyelin and other sphingolipids that prevent the development of intestinal tumors and butyric acid, which prevents colon and mammary tumor development. Emerging evidence suggests that milk fat can prevent intestinal infections, particularly in children, prevent allergic disorders, such as asthma and improve the level of long-chain co-3 polyunsaturated fatty acids in blood. 

El-Sohemy, A., Bruce, W.R., Archer, M.C. 1996b. Inhibition of rat mammary tumorigenesis by dietary cholesterol. Carcinogenesis. 17, 159-162. 

Hubbard, N.E., Lim, D., Erickson, K.L. 2003. Effect of separate conjugated linoleic acid isomers on murine mammary tumorigenesis. Cancer Lett. 190, 13-19. 

Yanagi, S., Yamashita, M., Imai, S. 1993. Sodium butyrate inhibits the enhancing effect of high fat diet on mammary tumorigenesis. Oncology. 50, 201-204. 

Deshpande, S.S., Ingle, A.D., and Mam, G.B., Chemopreventive efficacy of curcumin-free aqueous turmeric extract in 7,12-dimethylbenz[a] anthracene-induced rat mammary tumorigenesis. Cancer Lett., 123, 35, 1998. 

Singletary, K., MacDonald, C., Walhg, M., and Fisher, C., Inhihition of 7,12-dime-thylhenz[a] anthracene (DMBA)-induced mammary tumorigenesis and DMBA-DNA adduct formation hy curcumin. Cancer Lett., 103, 137, 1996. 

Webster, M. A. and Muller, W. J. (1994). Mammary tumorigenesis and metastasis in transgenic mice. Semin. Cancer Biol. 5, 69-76. 

Singletary, K.W. and Nelshoppen, J.M. 1991. Inhibition of 7,12-dimethylbenz(a)anthracene (DMBA)-induced mammary tumorigenesis and of in vivo formation of mammary DMBA-DNA adducts by rosemary extract. Cancer Lett. 60 169-175. 

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