Malignancy hormones

This seems plausible, as the time at which gonocytes become invasive coincides with periods during postnatal life and puberty when Sertoli cells are producing high amounts of hormones. The malignant gonocytes overexpress c-kit so it is possible that they might proliferate in response to stimulation by stem cell factor secreted by the Sertoli cells. ... 

FIGURE 96-4. Pathophysiology of the hypercalcemia of malignancy. PTHrP, parathyroid hormone-related protein TGF-P, transforming growth factor P TNF-a, tumor necrosis factor alpha Ca2+, calcium IL-1, interleukin 1 IL-2, interleukin 2. 

Testicular interstitial cell tumors occur spontaneously in aged rats, and the incidence can vary greatly in control groups. This tumor is believed to be hormonally mediated. There was no evidence of malignancy in three rat studies and no evidence of this type of tumor in mice. It can be concluded that the tumorigenic effect, if real, is most unlikely to be relevant to human exposure [13]. 

Pharmacological knowledge, gained with the discovery of steroid hormones, their nuclear receptors and their function in normal and malignant tissues, has been successfully translated into the first targeted drugs in oncology. 

Hormonal drugs are successfully used for complex treatment of malignant tumors. Tumors can be both hormone-dependent, as well as hormone-sensitive. 

Hepatic lesions (adenomas, focal nodular hyperplasia, hepatocellular carcinoma, etc) Rarely, benign and malignant hepatic adenomas have been associated with the use of hormonal contraceptives. Severe abdominal pain, shock, or death may be due to rupture and hemorrhage of a liver tumor. 

Gallium Nitrate (Ganite) [Hormone] Uses t Ca of malignancy bladdCT CA Action -1- bone resorption of Ca Dose t Ca 200 mg/mVd X 5 d CA 350 mg/m cont inf X 5 d to 700 mg/m rapid IV inf q2wk in antineoplastic settings (pCT protocols) Caution [C, ] Do not give w/ live or rotavirus vaccine Contra SCr >2.5 mg/dL Disp Inj SE Renal insuff, -1- Ca, hypophosphatemia, -1- bicarb, <1% acute optic neuritis Interactions t Risks of nephrotox amphotCTicin B,... 

Adenocarcinoma of the prostate is one of the most common malignant tumors in adult males. For advanced disease palliative hormonal therapy has been... 

Structurally homologous to the amino terminal portion of PTH and interacts with the PTH receptor in bone and kidney. This hormone is responsible for hypercalcemia in certain forms of malignancy. It has been used as a therapeutic agent in osteoporosis in some clinical trials. 

Although steroids have been studied for many years, steroid hormones continue to be a rich area of medicinal chemistry study. Steroids continue to be evaluated for their therapeutic role in the treatment of cancer, especially malignancies whose growth characteristics are hormonally responsive. In recent years, the increased recognition of the role of steroids in the brain has resulted in ongoing projects to evaluate steroids as general anasthetics and anticonvulsants. Also, the search for compounds that bind to steroid receptors, but which are not steroidal in their molecular structure, is another important area of research. 

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