Homology, structural

Neidhart, D.J., et al. Mandelate racemase and muconate lactonizing enzyme are mechanistically distinct and structurally homologous. Nature 347 ... 

The structural homology between intermediate 4 and isostrych-nine I (3) is obvious intermediates 3 and 4 are simply allylic isomers and the synthetic problem is now reduced to isomerizing the latter substance into the former. Treatment of 4 with hydrogen bromide in acetic acid at 120°C results in the formation of a mixture of isomeric allylic bromides which is subsequently transformed into isostrychnine I (3) with boiling aqueous sulfuric acid. Following precedent established in 194810 and through the processes outlined in Scheme 8a, isostrychnine I (3) is converted smoothly to strychnine (1) upon treatment with potassium hydroxide in ethanol. Woodward s landmark total synthesis of strychnine (1) is now complete. 

In view of the structural homology, it is likely that the cluster binding subdomadn of Rieske proteins accommodating two metal ions has evolved from an archadc mononuclear metal binding domain. A simi-... 

Familial lipoprotein(a) excess Lp(a) consists of 1 mol of LDL attached to 1 mol of apo(a). Apo(a) shows structural homologies to plasminogen. Premature coronary heart disease due to atherosclerosis, plus thrombosis due to inhibition of fibrinolysis. 

Langhon, A., and Scott, M. P. (1984). Sequence of a Drosophila segmentation gene protein structure homology with DNA-binding proteins. Nature 310 25-31. 

D CRYSTAL STRUCTURES HOMOLOGY MODELLING MOLECULAR SIMILARITY ... 

Structurally dissimilar, active molecules provide more information about the site than a series of active close structural homologs. 

S. D. Gamage, A. A. Weiss, and S. S. Iyer, Differentiation between structurally homologous Shiga 1 and Shiga 2 toxins by using synthetic glycoconjugates, Angew. Chem. Int. Ed., 47 (2008) 1265-1268. 

Although there is structural homology among the transporters for 5-HT, norepinephrine and dopamine, some drugs exhibit great selectivity at inhibiting the activity of just one of these proteins. For example, the selective norepinephrine re-uptake inhibitor reboxetine is 150 times more potent at inhibiting norepinephrine transport... 

Six functional families of ionotropic glutamate receptor subunit can be defined by structural homologies 273... 

It is worth mentioning that membrane-bound forms of GC, which can be considered signal transducing enzymes , are structurally homologous to other signal transducing enzymes, such as certain protein tyrosine kinases and phosphatases, which also possess receptor moieties in their extracellular (amino terminus) domain and enzyme catalytic activity in their intracellular domain (see Ch. 24). Activation of many of these receptors occurs upon ligand-induced dimerization of the receptors, and a similar... 

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