Lutropin

Angelova, K., Fanelli, F., and Puett, D. (2002) A model for constitutive lutropin receptor activation based on molecular simulation and engineered mutations in transmembrane helices 6 and 7. J. Biol. Chem. 211, 32202-32213. [Pg.256]

Li, S., Liu, X., Ascoli, M. p38JABl binds to the intracellular precursor of the lutropin/choriogonadotropin receptor and promotes its degradation. [Pg.365]

Liu, X., Davis, D., and Segaloff, D. L. (1993) Disruption of potential sites for N-hnked glyco-sylation does not impair hormone binding to the lutropin/choriogonadotropin receptor if Asn-173 is left intact. J. Biol. Chem. 268, 1513-1516. [Pg.98]

Min, L., and Ascoli, M. (2000) Effect of activating and inactivating mutations on the phosphorylation and trafficking of the human lutropin/choriogonadotropin receptor. Mol. Endocrinol. 14, 1797-1810. [Pg.108]

Many hormones are released into the blood in a spasmodic and irregular manner. In this case, their concentrations change in an episodic or pulsatile fashion. This applies, for instance, to luteinizing hormone (LH, lutropin). [Pg.372]

Thyrotropin (thyroid-stimulating hormone, TSH) and the related hormones lutropin (luteinizing hormone, LH) and follitropin (follicle-stimulating hormone, FSH) originate in the adenohypophysis. They are all dimeric glycoproteins with masses of around 28 kDa. Thyrotropin stimulates the synthesis and secretion of thyroxin by the thyroid gland. [Pg.380]

Lutropin Alfa (Luveris) Magnesium Sulfate (Various)... [Pg.54]

Lubiprostone (Amitiza) [Laxative] Uses Chronic idiopathic constipation in adults Action Selective Cl channel activator Dose Adults. 24 meg PO bid w/ food Contra Mechanical GI obst Caution [C, /-] Severe D, severe renal or mod-severe hepatic impair Disp Gel, caps meg SE N, HA, D, GI distention, abd pain EMS Monitor for signs of electrolyte disturbances and h5rpovolemia d/t D OD May cause severe D, hypovolemia, and abd pain/cramps give IV fluids Lutropin Alfa (Luveris) [Hormone] Uses Inf ility Action Recombinant LH Dose 75 Units SQ w/ 75—150 Units FSH, 2 s arate inj max 14 d Caution [X, /M] Contra Primary ovarian failure, uncontrolled thyroid/adrenal dysfxn, intracranial lesion, AUB, hormone-dqjendent GU tumor, ovarian cyst, PRG Disp Inj SE HA, N, ovarian h5rpCTstimulation synd, breast pain, ovarian cysts T risk of multiple births EMS None OD Unlikely to cause life-threatening Sxs... [Pg.211]

Luveris (lutropin-ot rhLH produced in CHO cells) OvitreDe also termed OvidreUe (rhCG, produced in CHO cells)... [Pg.501]

The menotropins, human menopausal gonadotropin (HMG) and urofollitropin are prepared from the urine of postmenopausal women. HMG has approximately equal amounts of FSH an LH. Urofollitropin has only FSH activity. Follitropin alpha and follitropin beta are two FSH products which are made with recombinant DNA technology. Lutropin alpha is recombinant human LH. Human chorionic gonadotropin (HCG) is produced in the placenta and excreted in the urine. It has mainly LH activity. Choriogonadotropin alpha is the world s first recombinant chorionic gonadotropin (r-hCG) for the treatment of anovulation, the most common cause of infertility in women. [Pg.388]

Lutropin (LH, luteinizing hormone, which in the male is called interstitial cell-stimulating hormone, ICSH)... [Pg.346]

Lutropin alfa, the recombinant form of human LH, was introduced in the USA in 2004. When given by subcutaneous injection, it has a half-life of about 10 hours. Lutropin has only been approved for use in combination with follitropin alfa for stimulation of follicular development in infertile women with profound LH deficiency. It has not been approved for use with the other preparations of FSH nor for simulating the endogenous LH surge that is needed to complete follicular development and precipitate ovulation. [Pg.834]

Parenteral depot polymeric delivery system 7.5, 22.5, 30, 45 mg in a single-dose kit for subcutaneous injection Parenteral depot microspheres suspension 3.75, 7.5, 11.25, 15, 22.5, 30 mg in a single-dose kit for IM injection Lutropin [rLH] (Luveris)... [Pg.849]

Thyrotropin (thyroid-stimulating hormone, TSH)b Follitropin (follicle-stimulating hormone, FH)b Lutropin (luteinizing hormone, ICSH or LH)b Thyroid Ovaries, testes Ovaries, testes Ch 25, B2... [Pg.1744]

Anonymous. Lutropin alfa combined with follitropin for follicular development no better than menotropin. Prescrire Int 2003 12 91-2. [Pg.207]

Eu3+, Tb3+, Sm3+, Dy3+ complexes have different emission wavelengths with sharp peak profiles, which are suitable for multi-component immunoassay. Several Eu-Sm two-color time-resolved immunoassays have been reported. Since the sensitivity of Sm3+ chelates is not high compared to Eu3+ and Tb3+, Eu-Sm two-color assays are used for the simultaneous determination of a low concentration component (Eu) and a relatively high concentration component (Sm) in serum the assayed combinations are lutropin and follitropin, myoglobin and carbonic dehydratase, AFP and free (3-subunit of human chorionic gonadotrophin (Hemmila et al., 1987). Use of Eu-Tb is reported by Eriksson et al. (2000) for the simultaneous determination of human serum free and total PSA. [Pg.195]

Luveris /Lutropin alfa Luteinizing hormone Female infertility... [Pg.394]

Wl. Wada, H. G., Danisch, R. J., Baxter, S. R., Federici, M. M., Fraser, R. C., Brownmill-er, L. J., and Lankford, J. C., Enzyme immunoassay of the glycoprotein tropic hormones—choriogonadotropin, lutropin, thyrotropin—with solid-phase monoclonal antibody for the a-subunit and enzyme-coupled monoclonal antibody specific for the fi-subunit. Clin. Chem. 28, 1862-1866 (1982). [Pg.109]

Synthetic peptides corresponding to various portions of a protein sequence have been used as powerful tools with which to investigate interactions between subunits. For example, two contact sites on the a-subunit of human lutropin have been identified by this method.20) Peptides corresponding to the entire sequence of the a-subunit of lutropin were incubated in the presence of separated a- and /8-subunits, and the reconstitution of heterodimeric structure was monitored by difference absorption spectroscopy, reverse phase F1PLC and gel filtration (Table 3.1). After a 24-hour incubation, peptide 33-58... [Pg.58]

Table 3.1 Reconstitution of heterodimeric structure of lutropin in the presence of peptides corresponding to the entire sequence of the or-subunit20 ...

Abbreviations ABP, androgen-binding protein 5q-DHT. 5a-dihydrotestosterone 5/3-DHT, 5/3-dihy-drotestosterone EGF, epidermal growth factor FSH. folitropin KAP, kidney androgen-induced protein LH, lutropin NGF, nerve growth factor SGF, testis-specific growth factor. [Pg.169]

LI. Landy, H., Schneyer, A. L., Whitcomb, R. W., and Crowley, W. F., Validation of highly specific and sensitive radioimmunoassays for lutropin, follitropin, and free alpha subunit in unextracted urine. Clin. Chem. 36, 340-344 (1990). [Pg.325]

Lutropin alfa Luveris (Serono) LH surge during fertility therapy... [Pg.270]

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