Polymeric delivery system

W. R. Good in R. J. Kostekiik, ed., Polymeric Delivery Systems, Gordon and Breach Science Publishers, New York, 1978, pp. 139—153. 

Figure 6 also shows that the use of this polymeric delivery system, also known as the BIODEL polymeric drug delivery system, for BCNU greatly increases the time over which the brains of these animals are exposed to significant BCNU concentrations. The brains... 

Langer, R., Brem, H., and Tapper, D., BiocompatibiUty of polymeric delivery systems for macromolecules, J. Biomed. 

In this paper, then, the previously developed model (7) is extended to the calculation of erosion characteristics of a well described polymeric delivery system, the acid-catalyzed erosion of poly (ortho ester)s (2-6). This system is chosen as the example system because of the completeness of the data package in the open literature. It is expected that this modelling approach is also useful for other hydrolytically unstable polymeric drug delivery systems. 

A. Trouet, Carriers for bioactive materials, in Polymeric Delivery Systems (R. J. Kostelnik, ed.), Gordon Breach, New York, 1978, p. 157. 

DC Harsh, SH Gehrke. Modeling swelling behavior of cellulose ether hydrogels. In M El-Nokaly, D Piatt, B Charpentier, eds. Polymeric Delivery Systems. ACS Symp Ser 520. Washington, DC American Chemical Society, 1993, pp 105-134. 

Kostelnik, R. J., Ed. "Polymeric Delivery Systems Midland Macromolecular Monographs, Vol. 5 Gordon Breach New York, 1977. 

An interesting feature of current commercial products is that the polymer vehicles available for formulation have been limited to nonionic and anionic materials. The delivery vehicles available included off-the-shelf polymers such as carboxymethylcellulose, soluble starch, hydroxyethyl-cellulose, polyvinyl alcohol, poly(acrylic acid), and polyvinylpyrrolidone, or mixtures thereof. The choice of available polymeric delivery system primarily depends on component compatibility, aesthetics, and efficacy. However, by reliance upon available (off-the-shelf) systems, limitations on bioadhesion, drug bioavailability, contraceptive efficacy, and end-use characteristics has been limited. 

Yang DJ, Juang LR, Li C (1992) Evaluation of poly(dl-lactide) encapsulated radiopaque microspheres. In Magda EN (ed) Polymeric delivery system. Am Chem Soc Symposium... 

Parenteral depot polymeric delivery system 7.5, 22.5, 30, 45 mg in a single-dose kit for subcutaneous injection Parenteral depot microspheres suspension 3.75, 7.5, 11.25, 15, 22.5, 30 mg in a single-dose kit for IM injection Lutropin [rLH] (Luveris)... 

Harsh D, Gehrke SH (1993) In El-Nokaly M, Piatt D, Charpentier B (eds) Polymeric delivery systems. ACS symposium series 520. American Chemical Society, Washington, DC, p 105... 

As described earlier, carbohydrates have been used extensively in their native forms and as components of novel polymeric structures to transfer exogenous nucleic acids into cells. In addition, carbohydrates have also been conjugated to polymeric delivery systems as targeting moieties. While an extensive amount of work has been completed and continues to be published utilizing various carbohydrate... 

J. Kost and R. Langer. Responsive polymeric delivery systems. Adv. Drug Deliv. Rev. 46 125-148, 2001. 

Recent development in polymeric delivery systems for the controlled release of therapeutic agents has demonstrated that these systems not only can improve drug stability both in vitro and in vivo by protecting labile drugs from harmful conditions in the body, but also can increase residence time at the application site and enhance the activity duration of short half-life drugs. Therefore, compounds which otherwise would have to be discarded due to stability and bioavailability problems may be rendered useful through a proper choice of polymeric delivery system. 

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