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Follitropin beta

The menotropins, human menopausal gonadotropin (HMG) and urofollitropin are prepared from the urine of postmenopausal women. HMG has approximately equal amounts of FSH an LH. Urofollitropin has only FSH activity. Follitropin alpha and follitropin beta are two FSH products which are made with recombinant DNA technology. Lutropin alpha is recombinant human LH. Human chorionic gonadotropin (HCG) is produced in the placenta and excreted in the urine. It has mainly LH activity. Choriogonadotropin alpha is the world s first recombinant chorionic gonadotropin (r-hCG) for the treatment of anovulation, the most common cause of infertility in women. [Pg.388]

Dosage form Follistim consists of a sterile, freeze-dried cake intended for injection after reconstitution with sterile water for injection. Each vial of Follistim contains follitropin beta 75 international units (lU). [Pg.231]

E. Therapeutic response Follicle maturation during follitropin beta therapy is best monitored by daily ultrasonography and daily measurement of serum and/or urine estradiol levels. Ovulation may be clinically confirmed by an increase in serum progesterone as well as an elevation in basal body temperature. [Pg.232]

F. Role in therapy According to Micromedex, recombinant follitropin beta is preferred over urofollitropin (uFSH). It lacks contaminants, provides for greater... [Pg.232]

G. Other applications Micromedex notes that follitropin beta, in combination with human chorionic gonadotropin treatment results in near normal sperm concentration and motihty, but sperm morphology remained subnormal in a hypogo-nadotropic male. [Pg.232]

Follicle-stimulating hormone (FSH) products/ Organon Follitropin beta Follistim [TR in U.S.]... [Pg.508]

Development of multiple follicles, and induction of ovulation and pregnancy GI 12644092 follitropin beta chain precursor (FSH-beta) (FSH-B) PID gI2644092 Human follicle stimulating hormone PDB ID 1FL7... [Pg.573]

Three forms of purified FSH are available. Urofollitropin, also known as uFSH, is a purified preparation of human FSH that is extracted from the urine of postmenopausal women. Virtually all the LH activity has been removed through a form of immunoaffinity chromatography that uses anti-hCG antibodies. Two recombinant forms of FSH (rFSH) are also available follitropin alfa and follitropin beta. The amino acid sequences of these two products are identical to that of human FSH. They differ from each other and urofollitropin in the composition of the carbohydrate side chains. The rFSH preparations have a shorter half-life than preparations derived from human urine but stimulate estrogen secretion at least as efficiently and, in some studies, more efficiently. The rFSH preparations are considerably more expensive. [Pg.834]

Follitropin beta A recombinant product with the same peptide sequence as follitropin alfa but differs in its carbohydrate side chains ... [Pg.846]

Parenteral 37.5, 150 IU powder for injection Follitropin beta [FSH] (Follistim)... [Pg.878]

Antithrombotic agents alteplase, drotrecogin alfa, antithrombin III Antianemic darbopoetin alfa, erythropoietin Growth hormones follitropin alpha, follitropin beta, chorionic gonadotropin (Human)... [Pg.36]

Follitropin beta (FSH) Follistim (Organon) Ovulatory failure... [Pg.270]

EU follitropin beta protein Puregon Puregon Pen, Follistim, Follistim AQ Recombinant human FSH in its beta glycoform expressed in CHO cells Hormone... [Pg.469]

Follicle-stimulating hormone (FSH) 4 Follistim 15, 465 Follistim AQ 465 Follitropin alpha 463 Follitropin beta 465 Fondapparin sodium 457 Food and dmg administration (FDA) 49, 1559, 1639, 1765... [Pg.1856]

Follitropin beta is a gonadotropin that stimulates ovarian follicular growth in women who do not have primary ovarian failnre. It is indicated for development of mnltiple follicles in ovulatory patients participating in an assisted reprodnctive technology (ART) program and for indnction of ovnlation and pregnancy in anovulatory infertile patients in whom the cause of infertility is functional and not cansed by primary ovarian failure. [Pg.285]

Gonadotropins—Follitropin Alpha (Gonal-F) and Follitropin Beta (Fllllstim)... [Pg.227]

See other pages where Follitropin beta is mentioned: [Pg.589]    [Pg.616]    [Pg.590]    [Pg.619]    [Pg.606]    [Pg.229]    [Pg.230]    [Pg.231]    [Pg.231]    [Pg.231]    [Pg.232]    [Pg.232]    [Pg.456]    [Pg.482]    [Pg.508]    [Pg.849]    [Pg.415]    [Pg.20]    [Pg.269]    [Pg.177]    [Pg.125]    [Pg.285]    [Pg.702]    [Pg.224]    [Pg.227]    [Pg.316]    [Pg.347]   
See also in sourсe #XX -- [ Pg.231 ]

See also in sourсe #XX -- [ Pg.285 ]

See also in sourсe #XX -- [ Pg.138 , Pg.140 , Pg.194 ]

See also in sourсe #XX -- [ Pg.347 ]



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